ID   NDUA1_PANPA             Reviewed;          70 AA.
AC   Q7JGX4;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1;
DE   AltName: Full=Complex I-MWFE;
DE            Short=CI-MWFE;
DE   AltName: Full=NADH-ubiquinone oxidoreductase MWFE subunit;
GN   Name=NDUFA1;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11937507; DOI=10.1074/jbc.m202016200;
RA   Yadava N., Potluri P., Smith E.N., Bisevac A., Scheffler I.E.;
RT   "Species-specific and mutant MWFE proteins. Their effect on the assembly of
RT   a functional mammalian mitochondrial complex I.";
RL   J. Biol. Chem. 277:21221-21230(2002).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O15239}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:O15239}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O15239}; Single-pass membrane protein
CC       {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O15239}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA1 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AF495659; AAM18518.1; -; mRNA.
DR   RefSeq; XP_008951549.1; XM_008953301.1.
DR   AlphaFoldDB; Q7JGX4; -.
DR   SMR; Q7JGX4; -.
DR   STRING; 9597.XP_008951549.1; -.
DR   Ensembl; ENSPPAT00000031950; ENSPPAP00000009309; ENSPPAG00000027878.
DR   GeneID; 100983914; -.
DR   KEGG; pps:100983914; -.
DR   CTD; 4694; -.
DR   eggNOG; ENOG502S3S5; Eukaryota.
DR   GeneTree; ENSGT00390000007560; -.
DR   OMA; AYIHKFT; -.
DR   OrthoDB; 1608843at2759; -.
DR   Proteomes; UP000240080; Chromosome X.
DR   Bgee; ENSPPAG00000027878; Expressed in heart and 6 other tissues.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR017384; NADH_Ub_cplx-1_asu_su-1.
DR   PANTHER; PTHR17098; PTHR17098; 1.
DR   Pfam; PF15879; MWFE; 1.
DR   PIRSF; PIRSF038095; NDUA1; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Respiratory chain; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..70
FT                   /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT                   subunit 1"
FT                   /id="PRO_0000118819"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   70 AA;  8099 MW;  F8D18762117BF253 CRC64;
     MWFEILPGLS VMGVCLLIPG LATAYIHRFT NGGKEKRVAH FGYHWNLMER DRRISGVDRY
     YVSKGLENID