ID   NDUA1_VARRB             Reviewed;          70 AA.
AC   Q8SPS2;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1;
DE   AltName: Full=Complex I-MWFE;
DE            Short=CI-MWFE;
DE   AltName: Full=NADH-ubiquinone oxidoreductase MWFE subunit;
GN   Name=NDUFA1;
OS   Varecia rubra (Red ruffed lemur) (Varecia variegata rubra).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Lemuridae; Varecia.
OX   NCBI_TaxID=554167;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11937507; DOI=10.1074/jbc.m202016200;
RA   Yadava N., Potluri P., Smith E.N., Bisevac A., Scheffler I.E.;
RT   "Species-specific and mutant MWFE proteins. Their effect on the assembly of
RT   a functional mammalian mitochondrial complex I.";
RL   J. Biol. Chem. 277:21221-21230(2002).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O15239}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:O15239}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O15239}; Single-pass membrane protein
CC       {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O15239}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA1 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AF495660; AAM18519.1; -; mRNA.
DR   AlphaFoldDB; Q8SPS2; -.
DR   SMR; Q8SPS2; -.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR017384; NADH_Ub_cplx-1_asu_su-1.
DR   PANTHER; PTHR17098; PTHR17098; 1.
DR   Pfam; PF15879; MWFE; 1.
DR   PIRSF; PIRSF038095; NDUA1; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..70
FT                   /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT                   subunit 1"
FT                   /id="PRO_0000251798"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   70 AA;  8094 MW;  A56E870019CE209A CRC64;
     MWFEILPGIA VMGTCLVIPG LATAYIHRFT NGGKEKRVAH FVYHWDLMER DRHISGVNRY
     YVSKGLENID