NDUA2_MACFA
ID NDUA2_MACFA Reviewed; 99 AA.
AC Q4R5E2;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2;
DE AltName: Full=Complex I-B8;
DE Short=CI-B8;
DE AltName: Full=NADH-ubiquinone oxidoreductase B8 subunit;
GN Name=NDUFA2; ORFNames=QnpA-16235;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Parietal cortex;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O43678}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O43678}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O43678}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O43678}; Matrix side
CC {ECO:0000250|UniProtKB:O43678}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA2 subunit family.
CC {ECO:0000305}.
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DR EMBL; AB169602; BAE01683.1; -; mRNA.
DR RefSeq; NP_001270545.1; NM_001283616.2.
DR AlphaFoldDB; Q4R5E2; -.
DR SMR; Q4R5E2; -.
DR STRING; 9541.XP_005558050.1; -.
DR Ensembl; ENSMFAT00000092685; ENSMFAP00000046180; ENSMFAG00000049634.
DR GeneID; 101925194; -.
DR KEGG; mcf:101925194; -.
DR CTD; 4695; -.
DR VEuPathDB; HostDB:ENSMFAG00000034109; -.
DR eggNOG; KOG3446; Eukaryota.
DR GeneTree; ENSGT00390000006178; -.
DR OMA; FIEQQYV; -.
DR OrthoDB; 1633416at2759; -.
DR Proteomes; UP000233100; Chromosome 6.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR016464; NADH_Ub_cplx-1_asu_su-2.
DR InterPro; IPR007741; Ribosome/NADH_DH.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12878; PTHR12878; 1.
DR Pfam; PF05047; L51_S25_CI-B8; 1.
DR PIRSF; PIRSF005822; NDUA2; 1.
DR SMART; SM00916; L51_S25_CI-B8; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 3: Inferred from homology;
KW Acetylation; Disulfide bond; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O43678"
FT CHAIN 2..99
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 2"
FT /id="PRO_0000234300"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:O43678"
FT MOD_RES 64
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9CQ75"
FT MOD_RES 64
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9CQ75"
FT MOD_RES 75
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9CQ75"
FT DISULFID 24..58
FT /note="Redox-active"
FT /evidence="ECO:0000250"
SQ SEQUENCE 99 AA; 10963 MW; F1ED6F07CD400318 CRC64;
MAAAAASRGI GAKLGLREIR IHLCQRSPGS QGVRDFIEKR YVELKKANPD LPILIRECSD
VQPKLWARYA FGQEKNVPLN NFSADQVTRA LENVLSGKA
