ID   NDUA2_NEUCR             Reviewed;          94 AA.
AC   Q07842; Q7SEX5;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 133.
DE   RecName: Full=NADH-ubiquinone oxidoreductase 10.5 kDa subunit;
DE   AltName: Full=Complex I;
DE            Short=CI;
GN   Name=nuo-10.5; ORFNames=NCU03156;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8448210; DOI=10.1016/0167-4781(93)90223-z;
RA   Duarte M., Belo J.A., Videira A.;
RT   "Primary structure of the nuclear-encoded 10.5 kDa subunit of complex I
RT   from Neurospora crassa.";
RL   Biochim. Biophys. Acta 1172:327-328(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC   -!- SUBUNIT: Complex I is composed of about 40 different subunits.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane
CC       protein; Matrix side.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA2 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; X69929; CAA49549.1; -; mRNA.
DR   EMBL; CM002236; EAA35326.1; -; Genomic_DNA.
DR   PIR; S30186; S30186.
DR   RefSeq; XP_964562.1; XM_959469.2.
DR   AlphaFoldDB; Q07842; -.
DR   SMR; Q07842; -.
DR   STRING; 5141.EFNCRP00000002938; -.
DR   TCDB; 3.D.1.6.2; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR   EnsemblFungi; EAA35326; EAA35326; NCU03156.
DR   GeneID; 3880727; -.
DR   KEGG; ncr:NCU03156; -.
DR   VEuPathDB; FungiDB:NCU03156; -.
DR   HOGENOM; CLU_110897_1_0_1; -.
DR   InParanoid; Q07842; -.
DR   OMA; FIEQQYV; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR   InterPro; IPR016464; NADH_Ub_cplx-1_asu_su-2.
DR   InterPro; IPR007741; Ribosome/NADH_DH.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR12878; PTHR12878; 1.
DR   Pfam; PF05047; L51_S25_CI-B8; 1.
DR   PIRSF; PIRSF005822; NDUA2; 1.
DR   SMART; SM00916; L51_S25_CI-B8; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Respiratory chain; Transport.
FT   CHAIN           1..94
FT                   /note="NADH-ubiquinone oxidoreductase 10.5 kDa subunit"
FT                   /id="PRO_0000118791"
SQ   SEQUENCE   94 AA;  10531 MW;  6CAAA3BDD59A37CF CRC64;
     MSGRFAFNKG LKEVRFLFCQ TGEHSAATRS FLLRNYPAMK KDNPATPILI RDASGTLPKV
     YARFEFGKEK SQSLEGLSDQ QIEETVSSLV KNNS