NDUA2_PONAB
ID NDUA2_PONAB Reviewed; 103 AA.
AC P0CB79; Q5R5Z4;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2;
DE AltName: Full=Complex I-B8;
DE Short=CI-B8;
DE AltName: Full=NADH-ubiquinone oxidoreductase B8 subunit;
GN Name=NDUFA2;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O43678}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O43678}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O43678}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O43678}; Matrix side
CC {ECO:0000250|UniProtKB:O43678}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA2 subunit family.
CC {ECO:0000305}.
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DR EMBL; CR860706; CAH92822.1; -; mRNA.
DR RefSeq; NP_001126649.1; NM_001133177.1.
DR AlphaFoldDB; P0CB79; -.
DR SMR; P0CB79; -.
DR STRING; 9601.ENSPPYP00000017734; -.
DR Ensembl; ENSPPYT00000061441; ENSPPYP00000041387; ENSPPYG00000036662.
DR GeneID; 100173647; -.
DR KEGG; pon:100173647; -.
DR CTD; 4695; -.
DR eggNOG; KOG3446; Eukaryota.
DR GeneTree; ENSGT00390000006178; -.
DR HOGENOM; CLU_110897_0_0_1; -.
DR InParanoid; P0CB79; -.
DR OMA; FIEQQYV; -.
DR OrthoDB; 1633416at2759; -.
DR TreeFam; TF300229; -.
DR Proteomes; UP000001595; Chromosome 5.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR016464; NADH_Ub_cplx-1_asu_su-2.
DR InterPro; IPR007741; Ribosome/NADH_DH.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12878; PTHR12878; 1.
DR Pfam; PF05047; L51_S25_CI-B8; 1.
DR PIRSF; PIRSF005822; NDUA2; 1.
DR SMART; SM00916; L51_S25_CI-B8; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 3: Inferred from homology;
KW Acetylation; Disulfide bond; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O43678"
FT CHAIN 2..103
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 2"
FT /id="PRO_0000250208"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:O43678"
FT MOD_RES 64
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9CQ75"
FT MOD_RES 64
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9CQ75"
FT MOD_RES 75
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9CQ75"
FT DISULFID 24..58
FT /note="Redox-active"
FT /evidence="ECO:0000250"
SQ SEQUENCE 103 AA; 11477 MW; 0C370373A1E55001 CRC64;
MAAAAASRGI GAKLGLREIR IHLCQRSPGS QGVRDFIEKR YVELKKANPD LPILIRECSD
VQPKLWARYA FGQEKNVPLN NFSADQVTRA LENVLKPEAS TED
