NDUA3_BOVIN
ID NDUA3_BOVIN Reviewed; 84 AA.
AC Q02371; Q3SZS6;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3;
DE AltName: Full=Complex I-B9;
DE Short=CI-B9;
DE AltName: Full=NADH-ubiquinone oxidoreductase B9 subunit;
GN Name=NDUFA3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 44-74.
RC TISSUE=Heart;
RX PubMed=1518044; DOI=10.1016/0022-2836(92)91052-q;
RA Walker J.E., Arizmendi J.M., Dupuis A., Fearnley I.M., Finel M., Medd S.M.,
RA Pilkington S.J., Runswick M.J., Skehel J.M.;
RT "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine
RT heart mitochondria. Application of a novel strategy for sequencing proteins
RT using the polymerase chain reaction.";
RL J. Mol. Biol. 226:1051-1072(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP ACETYLATION AT ALA-2.
RX PubMed=7958365; DOI=10.1042/bst0220551;
RA Fearnley I.M., Skehel J.M., Walker J.E.;
RT "Electrospray ionization mass spectrometric analysis of subunits of
RT NADH:ubiquinone oxidoreductase (complex I) from bovine heart
RT mitochondria.";
RL Biochem. Soc. Trans. 22:551-555(1994).
RN [4]
RP SUBUNIT, IDENTIFICATION IN COMPLEX I, AND SUBCELLULAR LOCATION.
RX PubMed=18721790; DOI=10.1016/j.ab.2008.07.029;
RA Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A.,
RA Robinson N.C.;
RT "Subunit analysis of bovine heart complex I by reversed-phase high-
RT performance liquid chromatography, electrospray ionization-tandem mass
RT spectrometry, and matrix-assisted laser desorption/ionization-time-of-
RT flight mass spectrometry.";
RL Anal. Biochem. 382:116-121(2008).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O95167}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000269|PubMed:1518044, ECO:0000269|PubMed:18721790}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000305|PubMed:18721790}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA3 subunit family.
CC {ECO:0000305}.
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DR EMBL; X63217; CAA44902.1; -; mRNA.
DR EMBL; BC102727; AAI02728.1; -; mRNA.
DR PIR; S28248; S28248.
DR RefSeq; NP_788832.1; NM_176659.2.
DR PDB; 5LC5; EM; 4.35 A; b=2-46.
DR PDB; 5LDW; EM; 4.27 A; b=2-46.
DR PDB; 5LDX; EM; 5.60 A; b=2-46.
DR PDB; 5O31; EM; 4.13 A; b=2-46.
DR PDB; 7QSD; EM; 3.10 A; b=1-84.
DR PDBsum; 5LC5; -.
DR PDBsum; 5LDW; -.
DR PDBsum; 5LDX; -.
DR PDBsum; 5O31; -.
DR PDBsum; 7QSD; -.
DR AlphaFoldDB; Q02371; -.
DR SMR; Q02371; -.
DR CORUM; Q02371; -.
DR DIP; DIP-38801N; -.
DR IntAct; Q02371; 3.
DR STRING; 9913.ENSBTAP00000010193; -.
DR TCDB; 3.D.1.6.1; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR iPTMnet; Q02371; -.
DR PaxDb; Q02371; -.
DR Ensembl; ENSBTAT00000010193; ENSBTAP00000010193; ENSBTAG00000007754.
DR GeneID; 338064; -.
DR KEGG; bta:338064; -.
DR CTD; 4696; -.
DR VEuPathDB; HostDB:ENSBTAG00000007754; -.
DR eggNOG; ENOG502S4RS; Eukaryota.
DR GeneTree; ENSGT00390000004322; -.
DR HOGENOM; CLU_171491_0_0_1; -.
DR InParanoid; Q02371; -.
DR OMA; PDIPAHP; -.
DR OrthoDB; 1577370at2759; -.
DR TreeFam; TF333021; -.
DR Reactome; R-BTA-611105; Respiratory electron transport.
DR Reactome; R-BTA-6799198; Complex I biogenesis.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000007754; Expressed in laryngeal cartilage and 105 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR026626; NDUFA3.
DR PANTHER; PTHR15221; PTHR15221; 1.
DR Pfam; PF14987; NADHdh_A3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Direct protein sequencing; Electron transport;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:7958365"
FT CHAIN 2..84
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 3"
FT /id="PRO_0000118792"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 56..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000269|PubMed:7958365"
SQ SEQUENCE 84 AA; 9349 MW; C2E60366AF5ADDBF CRC64;
MAERVAAFLK NVWAKEPVLV ASFAIAGLAV ILPTLSPYTK YSLMINRATP YNYPVPLRDD
GNMPDVPSHP QDPQGPSLEW LKRL
