ID   NDUA4_GORGO             Reviewed;          81 AA.
AC   Q0MQ98;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Cytochrome c oxidase subunit NDUFA4;
GN   Name=NDUFA4;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA   Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA   Wallace D.C.;
RT   "Adaptive selection of mitochondrial complex I subunits during primate
RT   radiation.";
RL   Gene 378:11-18(2006).
CC   -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC       mitochondrial electron transport chain which drives oxidative
CC       phosphorylation. The respiratory chain contains 3 multisubunit
CC       complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC       cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC       CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC       transfer electrons derived from NADH and succinate to molecular oxygen,
CC       creating an electrochemical gradient over the inner membrane that
CC       drives transmembrane transport and the ATP synthase. Cytochrome c
CC       oxidase is the component of the respiratory chain that catalyzes the
CC       reduction of oxygen to water. Electrons originating from reduced
CC       cytochrome c in the intermembrane space (IMS) are transferred via the
CC       dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC       to the active site in subunit 1, a binuclear center (BNC) formed by
CC       heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC       water molecules unsing 4 electrons from cytochrome c in the IMS and 4
CC       protons from the mitochondrial matrix. NDUFA4 is required for complex
CC       IV maintenance. {ECO:0000250|UniProtKB:O00483}.
CC   -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC       multisubunit enzyme composed of 14 subunits. The complex is composed of
CC       a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC       the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A,
CC       COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which
CC       are encoded in the nuclear genome. The complex exists as a monomer or a
CC       dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC       membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC       ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC       III, CIII), resulting in different assemblies (supercomplex
CC       SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity).
CC       Interacts with RAB5IF (By similarity). {ECO:0000250|UniProtKB:O00483}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O00483}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:O00483}.
CC   -!- SIMILARITY: Belongs to the complex IV NDUFA4 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; DQ885736; ABH12245.1; -; mRNA.
DR   RefSeq; XP_004045156.1; XM_004045108.2.
DR   AlphaFoldDB; Q0MQ98; -.
DR   SMR; Q0MQ98; -.
DR   STRING; 9593.ENSGGOP00000001421; -.
DR   Ensembl; ENSGGOT00000001447; ENSGGOP00000001421; ENSGGOG00000001437.
DR   GeneID; 101124353; -.
DR   KEGG; ggo:101124353; -.
DR   CTD; 4697; -.
DR   eggNOG; ENOG502S65P; Eukaryota.
DR   GeneTree; ENSGT00940000154268; -.
DR   HOGENOM; CLU_181002_0_0_1; -.
DR   InParanoid; Q0MQ98; -.
DR   OMA; AMSMMYL; -.
DR   OrthoDB; 1552648at2759; -.
DR   Proteomes; UP000001519; Chromosome 7.
DR   Bgee; ENSGGOG00000001437; Expressed in heart and 6 other tissues.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR   GO; GO:0005751; C:mitochondrial respiratory chain complex IV; ISS:UniProtKB.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:1904960; P:positive regulation of cytochrome-c oxidase activity; ISS:UniProtKB.
DR   InterPro; IPR010530; B12D.
DR   PANTHER; PTHR14256; PTHR14256; 1.
DR   Pfam; PF06522; B12D; 1.
PE   3: Inferred from homology;
KW   Acetylation; Electron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Phosphoprotein; Reference proteome;
KW   Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..81
FT                   /note="Cytochrome c oxidase subunit NDUFA4"
FT                   /id="PRO_0000251164"
FT   TOPO_DOM        1..14
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:O00483"
FT   TRANSMEM        15..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:O00483"
FT   TOPO_DOM        38..81
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:O00483"
FT   MOD_RES         10
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q62425"
FT   MOD_RES         66
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O00483"
SQ   SEQUENCE   81 AA;  9329 MW;  28B6592DCAEE24C7 CRC64;
     MLRQIIGQAK KHPSLIPLFV FIGTGATGAT LYLLRLALFN PDVCWDKSKP EPWNKLGPND
     QYKFYSVNVD YSKLKKERPD F