NDUA5_GORGO
ID NDUA5_GORGO Reviewed; 116 AA.
AC Q0MQA1;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5;
DE AltName: Full=Complex I subunit B13;
DE AltName: Full=Complex I-13kD-B;
DE Short=CI-13kD-B;
DE AltName: Full=NADH-ubiquinone oxidoreductase 13 kDa-B subunit;
GN Name=NDUFA5;
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA Wallace D.C.;
RT "Adaptive selection of mitochondrial complex I subunits during primate
RT radiation.";
RL Gene 378:11-18(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:Q16718}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:Q16718}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q16718}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q16718}; Matrix side
CC {ECO:0000250|UniProtKB:Q16718}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA5 subunit family.
CC {ECO:0000305}.
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DR EMBL; DQ885733; ABH12242.1; -; mRNA.
DR RefSeq; NP_001266684.1; NM_001279755.1.
DR AlphaFoldDB; Q0MQA1; -.
DR SMR; Q0MQA1; -.
DR STRING; 9593.ENSGGOP00000026477; -.
DR Ensembl; ENSGGOT00000068681; ENSGGOP00000040760; ENSGGOG00000022922.
DR GeneID; 101148914; -.
DR KEGG; ggo:101148914; -.
DR CTD; 4698; -.
DR eggNOG; KOG3365; Eukaryota.
DR GeneTree; ENSGT00390000008099; -.
DR HOGENOM; CLU_099943_2_0_1; -.
DR InParanoid; Q0MQA1; -.
DR OMA; VNEHPHR; -.
DR OrthoDB; 1372253at2759; -.
DR Proteomes; UP000001519; Chromosome 7.
DR Bgee; ENSGGOG00000022922; Expressed in heart and 6 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR GO; GO:0022904; P:respiratory electron transport chain; IBA:GO_Central.
DR InterPro; IPR006806; NDUFA5.
DR PANTHER; PTHR12653; PTHR12653; 1.
DR Pfam; PF04716; ETC_C1_NDUFA5; 1.
PE 3: Inferred from homology;
KW Acetylation; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P23935"
FT CHAIN 2..116
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 5"
FT /id="PRO_0000251803"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P23935"
FT MOD_RES 30
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q16718"
FT MOD_RES 46
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9CPP6"
FT MOD_RES 60
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q16718"
FT MOD_RES 98
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9CPP6"
FT MOD_RES 98
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9CPP6"
SQ SEQUENCE 116 AA; 13459 MW; 652339C1127E6F22 CRC64;
MAGVLKKTTG LVGLAVCNTP HERLRILYTK ILDVLEEIPK NAAYRKYTEQ ITNEKLAMVK
AEPDVKKLED QLQGGQLEEV ILQAEHELNL ARKMREWKLW EPLVEEPPAD QWKWPI
