ID   NDUA5_NEUCR             Reviewed;         273 AA.
AC   P24919; Q7RVF5;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 131.
DE   RecName: Full=NADH-ubiquinone oxidoreductase 29.9 kDa subunit, mitochondrial;
DE   AltName: Full=Complex I-29.9kD;
DE            Short=CI-29.9kD;
DE   Flags: Precursor;
GN   Name=nuo-32; ORFNames=NCU05299;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 9-31.
RC   STRAIN=74-ORS-6a / FGSC 4200;
RX   PubMed=1830489; DOI=10.1016/0167-4781(91)90181-k;
RA   van der Pas J.C., Roehlen D.-A., Weidner U., Weiss H.;
RT   "Primary structure of the nuclear-encoded 29.9 kDa subunit of NADH:
RT   ubiquinone reductase from Neurospora crassa mitochondria.";
RL   Biochim. Biophys. Acta 1089:389-390(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC   -!- SUBUNIT: Complex I is composed of about 40 different subunits.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane
CC       protein; Matrix side.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA5 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; X56237; CAA39694.1; -; mRNA.
DR   EMBL; CM002239; EAA32834.1; -; Genomic_DNA.
DR   PIR; S17191; S17191.
DR   RefSeq; XP_962070.1; XM_956977.2.
DR   AlphaFoldDB; P24919; -.
DR   STRING; 5141.EFNCRP00000004933; -.
DR   TCDB; 3.D.1.6.2; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR   EnsemblFungi; EAA32834; EAA32834; NCU05299.
DR   GeneID; 3878218; -.
DR   KEGG; ncr:NCU05299; -.
DR   VEuPathDB; FungiDB:NCU05299; -.
DR   HOGENOM; CLU_084284_0_0_1; -.
DR   InParanoid; P24919; -.
DR   OMA; PEGQWSY; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR   GO; GO:0022904; P:respiratory electron transport chain; IEA:InterPro.
DR   InterPro; IPR006806; NDUFA5.
DR   PANTHER; PTHR12653; PTHR12653; 1.
DR   Pfam; PF04716; ETC_C1_NDUFA5; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Electron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW   Transit peptide; Transport.
FT   TRANSIT         1..8
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000269|PubMed:1830489"
FT   CHAIN           9..273
FT                   /note="NADH-ubiquinone oxidoreductase 29.9 kDa subunit,
FT                   mitochondrial"
FT                   /id="PRO_0000019996"
SQ   SEQUENCE   273 AA;  30862 MW;  4B1175993B47EEF1 CRC64;
     MRAALRLLAT ATATVRPSAR FLKPGSPTGL TGLGTHPSPR SALLYLYNHT LDKLKQIPEH
     SLYRQSAEAL TKHRLAIVEQ YVPDGYDAWQ ERARKLLEKH KSDLTARQFD GQHARLVEGP
     DGRAYFIRQM VPPQDWRDVE WDGAVLDPHF SWVQTGEDVV GAVKLEDSDK LLELDKIRES
     DPVAYRQGLR DLGIKMGGVV EDKSPVEWES EPPLSAEQIA EMEARIGSGL IEEVVQVAEG
     ELKLVDIMTQ ARPWEALEEE APEGQWTYFE RKE