NDUA5_RAT
ID NDUA5_RAT Reviewed; 116 AA.
AC Q63362;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5;
DE AltName: Full=Complex I subunit B13;
DE AltName: Full=Complex I-13kD-B;
DE Short=CI-13kD-B;
DE AltName: Full=NADH-ubiquinone oxidoreductase 13 kDa-B subunit;
GN Name=Ndufa5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Brain;
RX PubMed=8875451; DOI=10.1080/01616412.1996.11740431;
RA Kitahara T., Takeda N., Kubo T., Kiyama H.;
RT "Molecular cloning of the rat NADH:ubiquinone oxidoreductase subunit and
RT its up-regulation in the facial muscle after denervation: detected by means
RT of differential display.";
RL Neurol. Res. 18:329-336(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 8-23 AND 67-86, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Sprague-Dawley; TISSUE=Spinal cord;
RA Lubec G., Afjehi-Sadat L.;
RL Submitted (NOV-2006) to UniProtKB.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:Q16718}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:Q16718}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q16718}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q16718}; Matrix side
CC {ECO:0000250|UniProtKB:Q16718}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA5 subunit family.
CC {ECO:0000305}.
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DR EMBL; D86215; BAA13045.1; -; mRNA.
DR EMBL; BC059148; AAH59148.1; -; mRNA.
DR RefSeq; NP_037117.1; NM_012985.2.
DR AlphaFoldDB; Q63362; -.
DR SMR; Q63362; -.
DR BioGRID; 247521; 1.
DR STRING; 10116.ENSRNOP00000008325; -.
DR CarbonylDB; Q63362; -.
DR iPTMnet; Q63362; -.
DR PhosphoSitePlus; Q63362; -.
DR jPOST; Q63362; -.
DR PaxDb; Q63362; -.
DR PRIDE; Q63362; -.
DR Ensembl; ENSRNOT00000096026; ENSRNOP00000078262; ENSRNOG00000071062.
DR GeneID; 25488; -.
DR KEGG; rno:25488; -.
DR UCSC; RGD:3155; rat.
DR CTD; 4698; -.
DR RGD; 3155; Ndufa5.
DR eggNOG; KOG3365; Eukaryota.
DR GeneTree; ENSGT00390000008099; -.
DR HOGENOM; CLU_099943_2_0_1; -.
DR InParanoid; Q63362; -.
DR OMA; VNEHPHR; -.
DR OrthoDB; 1372253at2759; -.
DR PhylomeDB; Q63362; -.
DR TreeFam; TF313785; -.
DR Reactome; R-RNO-611105; Respiratory electron transport.
DR Reactome; R-RNO-6799198; Complex I biogenesis.
DR Reactome; R-RNO-9013408; RHOG GTPase cycle.
DR PRO; PR:Q63362; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000005698; Expressed in heart and 20 other tissues.
DR Genevisible; Q63362; RN.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:RGD.
DR GO; GO:0032991; C:protein-containing complex; IDA:RGD.
DR GO; GO:0045271; C:respiratory chain complex I; ISO:RGD.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR GO; GO:0022904; P:respiratory electron transport chain; ISO:RGD.
DR InterPro; IPR006806; NDUFA5.
DR PANTHER; PTHR12653; PTHR12653; 1.
DR Pfam; PF04716; ETC_C1_NDUFA5; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Electron transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Phosphoprotein;
KW Reference proteome; Respiratory chain; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P23935"
FT CHAIN 2..116
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 5"
FT /id="PRO_0000118634"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P23935"
FT MOD_RES 30
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q16718"
FT MOD_RES 46
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9CPP6"
FT MOD_RES 60
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q16718"
FT MOD_RES 89
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 98
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9CPP6"
FT MOD_RES 98
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9CPP6"
SQ SEQUENCE 116 AA; 13412 MW; 12259F12B7D8C86C CRC64;
MAGLVKKTTG LVGLAVCDTP HERLTILYTK ILDLLKHFPK HAAYRKYTEQ ITSEKLELVK
LEPDVKKLEN LLQGGEVEEV ILQAEKELSL ARKMLQWKPW EPLVEEPPAN QWKWPI
