ID   NDUA6_BOVIN             Reviewed;         128 AA.
AC   Q02366; Q3T0E4;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 {ECO:0000250|UniProtKB:P56556};
DE   AltName: Full=Complex I-B14;
DE            Short=CI-B14;
DE   AltName: Full=NADH-ubiquinone oxidoreductase B14 subunit;
GN   Name=NDUFA6 {ECO:0000250|UniProtKB:P56556};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], ACETYLATION AT ALA-2, AND PARTIAL PROTEIN
RP   SEQUENCE.
RC   TISSUE=Heart;
RX   PubMed=1518044; DOI=10.1016/0022-2836(92)91052-q;
RA   Walker J.E., Arizmendi J.M., Dupuis A., Fearnley I.M., Finel M., Medd S.M.,
RA   Pilkington S.J., Runswick M.J., Skehel J.M.;
RT   "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine
RT   heart mitochondria. Application of a novel strategy for sequencing proteins
RT   using the polymerase chain reaction.";
RL   J. Mol. Biol. 226:1051-1072(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PARTIAL PROTEIN SEQUENCE, SUBUNIT, IDENTIFICATION IN COMPLEX I, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=10852722; DOI=10.1021/bi000335t;
RA   Sazanov L.A., Peak-Chew S.Y., Fearnley I.M., Walker J.E.;
RT   "Resolution of the membrane domain of bovine complex I into subcomplexes:
RT   implications for the structural organization of the enzyme.";
RL   Biochemistry 39:7229-7235(2000).
RN   [4]
RP   SUBUNIT, IDENTIFICATION IN COMPLEX I, AND SUBCELLULAR LOCATION.
RX   PubMed=18721790; DOI=10.1016/j.ab.2008.07.029;
RA   Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A.,
RA   Robinson N.C.;
RT   "Subunit analysis of bovine heart complex I by reversed-phase high-
RT   performance liquid chromatography, electrospray ionization-tandem mass
RT   spectrometry, and matrix-assisted laser desorption/ionization-time-of-
RT   flight mass spectrometry.";
RL   Anal. Biochem. 382:116-121(2008).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed to be not
CC       involved in catalysis. Required for proper complex I assembly. Complex
CC       I functions in the transfer of electrons from NADH to the respiratory
CC       chain. The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone. {ECO:0000250|UniProtKB:P56556}.
CC   -!- SUBUNIT: Mammalian complex I is composed of 45 different subunits.
CC       {ECO:0000269|PubMed:10852722, ECO:0000269|PubMed:18721790}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000305|PubMed:10852722, ECO:0000305|PubMed:18721790}; Peripheral
CC       membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the complex I LYR family. {ECO:0000305}.
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DR   EMBL; X63211; CAA44896.1; -; mRNA.
DR   EMBL; BC102430; AAI02431.1; -; mRNA.
DR   PIR; S28245; S28245.
DR   RefSeq; NP_786985.1; NM_175791.2.
DR   PDB; 5LC5; EM; 4.35 A; W=1-128.
DR   PDB; 5LDW; EM; 4.27 A; W=1-128.
DR   PDB; 5LDX; EM; 5.60 A; W=2-128.
DR   PDB; 5O31; EM; 4.13 A; W=1-128.
DR   PDB; 7QSD; EM; 3.10 A; W=1-128.
DR   PDBsum; 5LC5; -.
DR   PDBsum; 5LDW; -.
DR   PDBsum; 5LDX; -.
DR   PDBsum; 5O31; -.
DR   PDBsum; 7QSD; -.
DR   AlphaFoldDB; Q02366; -.
DR   SMR; Q02366; -.
DR   CORUM; Q02366; -.
DR   DIP; DIP-38828N; -.
DR   IntAct; Q02366; 3.
DR   STRING; 9913.ENSBTAP00000012512; -.
DR   TCDB; 3.D.1.6.1; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR   iPTMnet; Q02366; -.
DR   PaxDb; Q02366; -.
DR   PRIDE; Q02366; -.
DR   GeneID; 327670; -.
DR   KEGG; bta:327670; -.
DR   CTD; 4700; -.
DR   eggNOG; KOG3426; Eukaryota.
DR   HOGENOM; CLU_111660_3_0_1; -.
DR   InParanoid; Q02366; -.
DR   OrthoDB; 1518948at2759; -.
DR   TreeFam; TF105625; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   GO; GO:0006979; P:response to oxidative stress; IDA:UniProtKB.
DR   CDD; cd20266; Complex1_LYR_NDUFA6_LYRM6; 1.
DR   InterPro; IPR008011; Complex1_LYR_dom.
DR   InterPro; IPR045299; Complex1_LYR_NDUFA6_LYRM6.
DR   InterPro; IPR016488; NADH_Ub_cplx-1_asu_su-6.
DR   PANTHER; PTHR12964; PTHR12964; 1.
DR   Pfam; PF05347; Complex1_LYR; 1.
DR   PIRSF; PIRSF006643; NDUA6; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Direct protein sequencing; Electron transport;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Respiratory chain; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:1518044"
FT   CHAIN           2..128
FT                   /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT                   subunit 6"
FT                   /id="PRO_0000174301"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000269|PubMed:1518044"
SQ   SEQUENCE   128 AA;  15053 MW;  4DB92284502488BD CRC64;
     MAASGLRQAA VAASTSVKPI FSRDMNEAKR RVRELYRAWY REVPNTVHLF QLDISVKQGR
     DKVREMFKKN AHITDPRVVD LLVIKGKMEL EETIKVWKQR THVMRFFHET EAPRPKDFLS
     KFYVGHDP