ID   NDUA6_NEUCR             Reviewed;         124 AA.
AC   P42114; Q7RV70;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=NADH-ubiquinone oxidoreductase 14.8 kDa subunit;
DE   AltName: Full=Complex I-14.8KD;
DE            Short=CI-14.8KD;
GN   Name=nuo14.8; ORFNames=NCU00418;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-17.
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=8166654; DOI=10.1042/bj2990297;
RA   Azevedo J.E., Eckerskorn C., Werner S.;
RT   "In organello assembly of respiratory-chain complex I: primary structure of
RT   the 14.8 kDa subunit of Neurospora crassa complex I.";
RL   Biochem. J. 299:297-302(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed to be not
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone. The precise function of this
CC       subunit is unknown but believed to be important.
CC   -!- SUBUNIT: Complex I is composed of about 40 different subunits. Belongs
CC       to the peripheral arm of the complex, most likely the globular part.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane
CC       protein; Matrix side. Note=The import of this subunit is dependent on
CC       proteinaceous components of the mitochondrial outer membrane.
CC   -!- SIMILARITY: Belongs to the complex I LYR family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA28068.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; X76344; CAA53963.1; -; mRNA.
DR   EMBL; CM002238; EAA28068.3; ALT_INIT; Genomic_DNA.
DR   PIR; S43840; S43840.
DR   RefSeq; XP_957304.3; XM_952211.3.
DR   AlphaFoldDB; P42114; -.
DR   SMR; P42114; -.
DR   STRING; 5141.EFNCRP00000000331; -.
DR   TCDB; 3.D.1.6.2; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR   EnsemblFungi; EAA28068; EAA28068; NCU00418.
DR   GeneID; 3873451; -.
DR   KEGG; ncr:NCU00418; -.
DR   HOGENOM; CLU_111660_0_1_1; -.
DR   InParanoid; P42114; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR   GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR   CDD; cd20266; Complex1_LYR_NDUFA6_LYRM6; 1.
DR   InterPro; IPR008011; Complex1_LYR_dom.
DR   InterPro; IPR045299; Complex1_LYR_NDUFA6_LYRM6.
DR   InterPro; IPR016488; NADH_Ub_cplx-1_asu_su-6.
DR   PANTHER; PTHR12964; PTHR12964; 1.
DR   Pfam; PF05347; Complex1_LYR; 1.
DR   PIRSF; PIRSF006643; NDUA6; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Electron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW   Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:8166654"
FT   CHAIN           2..124
FT                   /note="NADH-ubiquinone oxidoreductase 14.8 kDa subunit"
FT                   /id="PRO_0000174304"
SQ   SEQUENCE   124 AA;  14812 MW;  03015DB4B623C1AD CRC64;
     MPITPTKYAI TTRQSANWSD AKRRVFALYR RWLRSTPEMQ SMYSLPLPIS VIRTRIRQEF
     ERNRFVNKLP VVDVLLTKGH ADYQETMNFW RQTTHMMSYF NEESFRGAKR LPSSFIDGFL
     QGRN