NDUA6_PANTR
ID NDUA6_PANTR Reviewed; 128 AA.
AC Q0MQA5;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 {ECO:0000250|UniProtKB:P56556};
DE AltName: Full=Complex I-B14;
DE Short=CI-B14;
DE AltName: Full=NADH-ubiquinone oxidoreductase B14 subunit;
GN Name=NDUFA6 {ECO:0000250|UniProtKB:P56556};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA Wallace D.C.;
RT "Adaptive selection of mitochondrial complex I subunits during primate
RT radiation.";
RL Gene 378:11-18(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed to be not
CC involved in catalysis. Required for proper complex I assembly. Complex
CC I functions in the transfer of electrons from NADH to the respiratory
CC chain. The immediate electron acceptor for the enzyme is believed to be
CC ubiquinone. {ECO:0000250|UniProtKB:P56556}.
CC -!- SUBUNIT: Mammalian complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P56556}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P56556}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P56556}; Matrix side
CC {ECO:0000250|UniProtKB:P56556}.
CC -!- SIMILARITY: Belongs to the complex I LYR family. {ECO:0000305}.
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DR EMBL; DQ885729; ABH12238.1; -; mRNA.
DR RefSeq; NP_001065259.1; NM_001071791.1.
DR AlphaFoldDB; Q0MQA5; -.
DR SMR; Q0MQA5; -.
DR STRING; 9598.ENSPTRP00000058761; -.
DR PaxDb; Q0MQA5; -.
DR GeneID; 458981; -.
DR KEGG; ptr:458981; -.
DR CTD; 4700; -.
DR eggNOG; KOG3426; Eukaryota.
DR HOGENOM; CLU_111660_3_0_1; -.
DR InParanoid; Q0MQA5; -.
DR OrthoDB; 1518948at2759; -.
DR TreeFam; TF105625; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR CDD; cd20266; Complex1_LYR_NDUFA6_LYRM6; 1.
DR InterPro; IPR008011; Complex1_LYR_dom.
DR InterPro; IPR045299; Complex1_LYR_NDUFA6_LYRM6.
DR InterPro; IPR016488; NADH_Ub_cplx-1_asu_su-6.
DR PANTHER; PTHR12964; PTHR12964; 1.
DR Pfam; PF05347; Complex1_LYR; 1.
DR PIRSF; PIRSF006643; NDUA6; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Phosphoprotein; Reference proteome;
KW Respiratory chain; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q02366"
FT CHAIN 2..128
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 6"
FT /id="PRO_0000251168"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q02366"
FT MOD_RES 11
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P56556"
SQ SEQUENCE 128 AA; 15137 MW; 5EE10C571A659D8B CRC64;
MAGSGVRQAT STASTFVKPI FSRDMNEAKR RVRELYRAWY REVPNTVHQF QLDITVKMGR
DKVREMFMKN AHVTDPRVVD LLVIKGKIEL EETIKVWKQR THVMRFFHET EAPRPKDFLS
KFYVGHDP
