NDUA8_DICDI
ID NDUA8_DICDI Reviewed; 104 AA.
AC Q54P46;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8;
GN Name=ndufa8; ORFNames=DDB_G0284799;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Complex I is composed of about 45 different subunits.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P51970}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P51970}. Mitochondrion intermembrane space
CC {ECO:0000250|UniProtKB:P51970}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA8 subunit family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000071; EAL65052.1; -; Genomic_DNA.
DR RefSeq; XP_638412.1; XM_633320.1.
DR AlphaFoldDB; Q54P46; -.
DR SMR; Q54P46; -.
DR STRING; 44689.DDB0233242; -.
DR PaxDb; Q54P46; -.
DR EnsemblProtists; EAL65052; EAL65052; DDB_G0284799.
DR GeneID; 8624782; -.
DR KEGG; ddi:DDB_G0284799; -.
DR dictyBase; DDB_G0284799; ndufa8.
DR eggNOG; ENOG502RIA4; Eukaryota.
DR HOGENOM; CLU_2255242_0_0_1; -.
DR InParanoid; Q54P46; -.
DR OMA; AFEKCKI; -.
DR PhylomeDB; Q54P46; -.
DR PRO; PR:Q54P46; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:dictyBase.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR016680; NDUFA8.
DR PANTHER; PTHR13344; PTHR13344; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS51808; CHCH; 2.
PE 3: Inferred from homology;
KW Disulfide bond; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat;
KW Respiratory chain; Transport.
FT CHAIN 1..104
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 8"
FT /id="PRO_0000327800"
FT DOMAIN 17..59
FT /note="CHCH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DOMAIN 60..102
FT /note="CHCH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 20..30
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 41..51
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 63..73
FT /note="Cx9C motif 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 84..94
FT /note="Cx9C motif 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 20..51
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 30..41
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 63..94
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 73..84
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 104 AA; 11919 MW; A9049E98F0759A61 CRC64;
MESFTRAELV AQRDGVWAVC GEVFEAYEKC RMEKGSDPEL CLRESTAVVG CSQKVMREIV
KNCQKELNES VKCIEENNMR TIPCEEENKA FNECFDKLVA PKFL
