ID   NDUA9_NEUCR             Reviewed;         375 AA.
AC   P25284; Q7RVA6;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   25-MAY-2022, entry version 143.
DE   RecName: Full=NADH-ubiquinone oxidoreductase 40 kDa subunit, mitochondrial;
DE   AltName: Full=Complex I-40kD;
DE            Short=CI-40kD;
DE   Flags: Precursor;
GN   Name=nuo40; ORFNames=NCU02373;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 27-45.
RC   STRAIN=74-ORS-6a / FGSC 4200;
RX   PubMed=1825202; DOI=10.1016/0014-5793(91)80087-j;
RA   Roehlen D.-A., Hoffmann J., van der Pas J.C., Nehls U., Preis D.,
RA   Sackmann U., Weiss H.;
RT   "Relationship between a subunit of NADH dehydrogenase (complex I) and a
RT   protein family including subunits of cytochrome reductase and processing
RT   protease of mitochondria.";
RL   FEBS Lett. 278:75-78(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC       Note=Binds 1 FAD per subunit.;
CC   -!- SUBUNIT: Complex I is composed of about 40 different subunits.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA9 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; X56238; CAA39695.1; -; Genomic_DNA.
DR   EMBL; CM002242; EAA30558.3; -; Genomic_DNA.
DR   PIR; S13025; S13025.
DR   RefSeq; XP_959794.3; XM_954701.3.
DR   AlphaFoldDB; P25284; -.
DR   SMR; P25284; -.
DR   STRING; 5141.EFNCRP00000003236; -.
DR   TCDB; 3.D.1.6.2; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR   EnsemblFungi; EAA30558; EAA30558; NCU02373.
DR   GeneID; 3875948; -.
DR   KEGG; ncr:NCU02373; -.
DR   VEuPathDB; FungiDB:NCU02373; -.
DR   HOGENOM; CLU_007383_6_4_1; -.
DR   InParanoid; P25284; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR   GO; GO:1901006; P:ubiquinone-6 biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR008030; NmrA-like.
DR   Pfam; PF05368; NmrA; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Electron transport; FAD; Flavoprotein;
KW   Mitochondrion; Reference proteome; Respiratory chain; Transit peptide;
KW   Transport.
FT   TRANSIT         1..26
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000269|PubMed:1825202"
FT   CHAIN           27..375
FT                   /note="NADH-ubiquinone oxidoreductase 40 kDa subunit,
FT                   mitochondrial"
FT                   /id="PRO_0000019994"
FT   CONFLICT        10
FT                   /note="S -> R (in Ref. 1; CAA39695)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        152
FT                   /note="A -> R (in Ref. 1; CAA39695)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   375 AA;  42870 MW;  D91B4A6FD207E584 CRC64;
     MAPLTAAMRS TPRIIVSNAF GFQRRAISDV TITRTGKPII RNQGGRSSLG GHTATVFGAT
     GQLGRYIVNR LARQGCTVVI PFRDEYNKRH LKVTGDLGKV VMIEFDLRNT QSIEESVRHS
     DVVYNLIGRD YPTKNFSFED VHIEGAERIA EAVAKYDVDR FIHVSSYNAD PNSECEFFAT
     KARGEQVVRS IFPETTIVRP APMFGFEDRL LHKLASVKNI LTSNGMQEKY NPVHVIDVGQ
     ALEQMLWDDN TASETFELYG PKTYTTAEIS EMVDREIYKR RRHVNVPKKI LKPIAGVLNK
     ALWWPIMSAD EIEREFHDQV IDPEAKTFKD LGIEPADIAN FTYHYLQSYR SNAYYDLPPA
     TEKERREDRE YIHML