ID   NDUAA_PONAB             Reviewed;         355 AA.
AC   P0CB89; Q0MQB5; Q5R9E8;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial;
DE   AltName: Full=Complex I-42kD;
DE            Short=CI-42kD;
DE   AltName: Full=NADH-ubiquinone oxidoreductase 42 kDa subunit;
DE   Flags: Precursor;
GN   Name=NDUFA10;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O95299}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits. This a
CC       component of the hydrophobic protein fraction.
CC       {ECO:0000250|UniProtKB:O95299}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:O95299}.
CC   -!- PTM: Phosphorylation at Ser-250 by PINK1 is required for the binding
CC       and/or reduction of the complex I substrate ubiquinone.
CC       {ECO:0000250|UniProtKB:Q99LC3}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA10 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; CR859441; CAH91612.1; -; mRNA.
DR   AlphaFoldDB; P0CB89; -.
DR   SMR; P0CB89; -.
DR   STRING; 9601.ENSPPYP00000014913; -.
DR   eggNOG; KOG3877; Eukaryota.
DR   InParanoid; P0CB89; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   CDD; cd02030; NDUO42; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR031314; DNK_dom.
DR   InterPro; IPR015828; NDUFA10.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01712; dNK; 1.
DR   PIRSF; PIRSF000543; NADH_UQ_42KD; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; FAD; Flavoprotein; Mitochondrion; Phosphoprotein;
KW   Reference proteome; Respiratory chain; Transit peptide; Transport.
FT   TRANSIT         1..35
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250|UniProtKB:P34942"
FT   CHAIN           36..355
FT                   /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT                   subunit 10, mitochondrial"
FT                   /id="PRO_0000234302"
FT   MOD_RES         250
FT                   /note="Phosphoserine; by PINK1"
FT                   /evidence="ECO:0000250|UniProtKB:Q99LC3"
FT   MOD_RES         285
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99LC3"
SQ   SEQUENCE   355 AA;  40715 MW;  78BB6AEACB15556E CRC64;
     MALRLLKLAP ASASARVVAA GAQRVRGIHS SVQCKLRYGM WRFLLGDKAS KRLTERSRVI
     TVDGNICTGK GKLAKEIAEK LGFKHFPEAG IHYPDSITGD GKPLAADYNG NCSLEKFYDD
     PRSNDGNTYR LQSWLYSSRL LQYSDALEHL LTTGQGVVLE RSIFSDFVFL DAMYNQGFIR
     KQCVDHYNEV KSVTICDYLP PHLVIYIDVP VPEVQRRIQK KGDPHEMKIT SAYLQDIENA
     YKKTFLPEMS EKCEVLQYSA REAQDSKKVV EDIEYLKFDK GPWLKQDNHT LYHLRLLVQD
     KFEVLNYTSI PVFLPEVTIG AHQTDRVLHQ FRELPGRKYS PGYNTEVGDK WIWLK