NDUAB_BOVIN
ID NDUAB_BOVIN Reviewed; 141 AA.
AC Q8HXG6; Q3ZC19;
DT 13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11;
DE AltName: Full=Complex I-B14.7;
DE Short=CI-B14.7;
DE AltName: Full=NADH-ubiquinone oxidoreductase subunit B14.7;
GN Name=NDUFA11;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND ACETYLATION AT
RP ALA-2.
RC TISSUE=Heart;
RX PubMed=12381726; DOI=10.1074/jbc.m209166200;
RA Carroll J., Shannon R.J., Fearnley I.M., Walker J.E., Hirst J.;
RT "Definition of the nuclear encoded protein composition of bovine heart
RT mitochondrial complex I. Identification two new subunits.";
RL J. Biol. Chem. 277:50311-50317(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP SUBCELLULAR LOCATION, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT
RP ALA-2, AND MASS SPECTROMETRY.
RX PubMed=17060615; DOI=10.1073/pnas.0607719103;
RA Carroll J., Fearnley I.M., Walker J.E.;
RT "Definition of the mitochondrial proteome by measurement of molecular
RT masses of membrane proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:16170-16175(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:Q86Y39}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000269|PubMed:12381726}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000305|PubMed:17060615}; Multi-pass membrane protein
CC {ECO:0000255}; Matrix side {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=14667.5; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:17060615};
CC -!- SIMILARITY: Belongs to the complex I NDUFA11 subunit family.
CC {ECO:0000305}.
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DR EMBL; AJ510148; CAD52867.1; -; mRNA.
DR EMBL; BC102976; AAI02977.1; -; mRNA.
DR RefSeq; NP_783649.1; NM_175718.2.
DR PDB; 5LC5; EM; 4.35 A; Y=2-139.
DR PDB; 5LDW; EM; 4.27 A; Y=1-141.
DR PDB; 5LDX; EM; 5.60 A; Y=2-141.
DR PDB; 5O31; EM; 4.13 A; Y=1-141.
DR PDB; 7QSD; EM; 3.10 A; Y=1-141.
DR PDBsum; 5LC5; -.
DR PDBsum; 5LDW; -.
DR PDBsum; 5LDX; -.
DR PDBsum; 5O31; -.
DR PDBsum; 7QSD; -.
DR AlphaFoldDB; Q8HXG6; -.
DR SMR; Q8HXG6; -.
DR CORUM; Q8HXG6; -.
DR DIP; DIP-38796N; -.
DR IntAct; Q8HXG6; 2.
DR STRING; 9913.ENSBTAP00000025322; -.
DR BindingDB; Q8HXG6; -.
DR ChEMBL; CHEMBL2503; -.
DR TCDB; 3.D.1.6.1; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR iPTMnet; Q8HXG6; -.
DR PaxDb; Q8HXG6; -.
DR PRIDE; Q8HXG6; -.
DR Ensembl; ENSBTAT00000025322; ENSBTAP00000025322; ENSBTAG00000019025.
DR GeneID; 326346; -.
DR KEGG; bta:326346; -.
DR CTD; 126328; -.
DR VEuPathDB; HostDB:ENSBTAG00000019025; -.
DR eggNOG; ENOG502S6F6; Eukaryota.
DR GeneTree; ENSGT00390000012434; -.
DR HOGENOM; CLU_134185_2_0_1; -.
DR InParanoid; Q8HXG6; -.
DR OMA; SIEQGWE; -.
DR OrthoDB; 1456214at2759; -.
DR TreeFam; TF314729; -.
DR Reactome; R-BTA-611105; Respiratory electron transport.
DR Reactome; R-BTA-6799198; Complex I biogenesis.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000019025; Expressed in tongue muscle and 107 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR039205; NDUFA11.
DR PANTHER; PTHR21382; PTHR21382; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Direct protein sequencing; Electron transport;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:12381726,
FT ECO:0000269|PubMed:17060615"
FT CHAIN 2..141
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 11"
FT /id="PRO_0000118840"
FT TRANSMEM 22..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000269|PubMed:12381726,
FT ECO:0000269|PubMed:17060615"
SQ SEQUENCE 141 AA; 14758 MW; 700A92AA15E431E4 CRC64;
MAKTVLRQYW DIPEGTECHR KTYATTSIGG AAGLVVSAYS VALKTPTSFL EGVARTGRYT
FTAAAIGAIF GLTSCISAQV REKPDDPLNY LIGGCAGGLI LGARTRSYGI GAAACAYMGL
TAALVKMGQL EGWQVFAEPK V
