NDUAC_BOVIN
ID NDUAC_BOVIN Reviewed; 145 AA.
AC O97725; Q3T092;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12;
DE AltName: Full=Complex I-B17.2;
DE Short=CI-B17.2;
DE Short=CIB17.2;
DE AltName: Full=NADH-ubiquinone oxidoreductase subunit B17.2;
GN Name=NDUFA12;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND ACETYLATION AT MET-1.
RC TISSUE=Heart;
RX PubMed=9827566; DOI=10.1016/s0014-5793(98)01317-9;
RA Skehel J.M., Fearnley I.M., Walker J.E.;
RT "NADH:ubiquinone oxidoreductase from bovine heart mitochondria: sequence of
RT a novel 17.2-kDa subunit.";
RL FEBS Lett. 438:301-305(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP SUBUNIT, IDENTIFICATION IN COMPLEX I, AND SUBCELLULAR LOCATION.
RX PubMed=18721790; DOI=10.1016/j.ab.2008.07.029;
RA Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A.,
RA Robinson N.C.;
RT "Subunit analysis of bovine heart complex I by reversed-phase high-
RT performance liquid chromatography, electrospray ionization-tandem mass
RT spectrometry, and matrix-assisted laser desorption/ionization-time-of-
RT flight mass spectrometry.";
RL Anal. Biochem. 382:116-121(2008).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:Q9UI09}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000269|PubMed:18721790}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000305|PubMed:18721790}; Peripheral membrane protein
CC {ECO:0000305}; Matrix side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA12 subunit family.
CC {ECO:0000305}.
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DR EMBL; AJ011400; CAA09608.1; -; mRNA.
DR EMBL; BC102502; AAI02503.1; -; mRNA.
DR RefSeq; NP_776731.1; NM_174306.3.
DR PDB; 5LC5; EM; 4.35 A; q=2-139.
DR PDB; 5LDW; EM; 4.27 A; q=1-145.
DR PDB; 5LDX; EM; 5.60 A; q=2-139.
DR PDB; 5O31; EM; 4.13 A; q=1-145.
DR PDB; 7QSD; EM; 3.10 A; q=1-145.
DR PDBsum; 5LC5; -.
DR PDBsum; 5LDW; -.
DR PDBsum; 5LDX; -.
DR PDBsum; 5O31; -.
DR PDBsum; 7QSD; -.
DR AlphaFoldDB; O97725; -.
DR SMR; O97725; -.
DR CORUM; O97725; -.
DR DIP; DIP-38802N; -.
DR IntAct; O97725; 3.
DR STRING; 9913.ENSBTAP00000019529; -.
DR TCDB; 3.D.1.6.1; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR iPTMnet; O97725; -.
DR PaxDb; O97725; -.
DR PRIDE; O97725; -.
DR GeneID; 281742; -.
DR KEGG; bta:281742; -.
DR CTD; 55967; -.
DR eggNOG; KOG3382; Eukaryota.
DR HOGENOM; CLU_110455_1_0_1; -.
DR InParanoid; O97725; -.
DR OrthoDB; 1475919at2759; -.
DR TreeFam; TF106106; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IDA:UniProtKB.
DR InterPro; IPR007763; NDUFA12.
DR PANTHER; PTHR12910; PTHR12910; 1.
DR Pfam; PF05071; NDUFA12; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transport.
FT CHAIN 1..145
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 12"
FT /id="PRO_0000118844"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000269|PubMed:9827566"
SQ SEQUENCE 145 AA; 17090 MW; 7471348CC3AD53C7 CRC64;
MELLQVLKRG LQQVSGHGGL RGYLRVLFRA NDVRVGTLVG EDKYGNKYYE DNKQFFGRHR
WVIYTTEMNG KNTFWDVDGS MVPPEWHRWL HCMTDDPPTV KPPTARKFIW TNHKFNLSGT
PQQYVPYSTT RKKIQEWVPP STPYK
