NDUAC_CAEEL
ID NDUAC_CAEEL Reviewed; 146 AA.
AC Q9N2W7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12;
DE AltName: Full=NADH-ubiquinone oxidoreductase 17.0 kDa subunit;
GN ORFNames=Y94H6A.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA12 subunit family.
CC {ECO:0000305}.
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DR EMBL; FO081810; CCD74208.1; -; Genomic_DNA.
DR RefSeq; NP_500247.2; NM_067846.4.
DR AlphaFoldDB; Q9N2W7; -.
DR SMR; Q9N2W7; -.
DR BioGRID; 42202; 58.
DR STRING; 6239.Y94H6A.8.2; -.
DR EPD; Q9N2W7; -.
DR PaxDb; Q9N2W7; -.
DR PeptideAtlas; Q9N2W7; -.
DR EnsemblMetazoa; Y94H6A.8.1; Y94H6A.8.1; WBGene00022380.
DR GeneID; 177056; -.
DR KEGG; cel:CELE_Y94H6A.8; -.
DR UCSC; Y94H6A.8.1; c. elegans.
DR CTD; 177056; -.
DR WormBase; Y94H6A.8; CE39995; WBGene00022380; -.
DR eggNOG; KOG3382; Eukaryota.
DR GeneTree; ENSGT00390000005848; -.
DR HOGENOM; CLU_110455_1_1_1; -.
DR InParanoid; Q9N2W7; -.
DR OMA; WHGWIHH; -.
DR OrthoDB; 1475919at2759; -.
DR PhylomeDB; Q9N2W7; -.
DR PRO; PR:Q9N2W7; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00022380; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:WormBase.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR InterPro; IPR007763; NDUFA12.
DR PANTHER; PTHR12910; PTHR12910; 1.
DR Pfam; PF05071; NDUFA12; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Respiratory chain; Transport.
FT CHAIN 1..146
FT /note="Probable NADH dehydrogenase [ubiquinone] 1 alpha
FT subcomplex subunit 12"
FT /id="PRO_0000118847"
SQ SEQUENCE 146 AA; 17073 MW; 0A8549D622977786 CRC64;
MSLKAWLGID KIQKFGQMVK EIGGVKAVLK KRYLMDATRV GTLVGSDNFG NRYYENNAYF
VPRNRWVEFP DKVWLDYDAT QVPPEWHSWL HHITDDAPSV KPPPTQDWVL EHKENTSIYA
DKKYVPYSTT RTKIQGWQPG EKPQFD