NDUAC_PANTR
ID NDUAC_PANTR Reviewed; 145 AA.
AC Q0MQ87;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12;
DE AltName: Full=Complex I-B17.2;
DE Short=CI-B17.2;
DE Short=CIB17.2;
DE AltName: Full=NADH-ubiquinone oxidoreductase subunit B17.2;
GN Name=NDUFA12;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA Wallace D.C.;
RT "Adaptive selection of mitochondrial complex I subunits during primate
RT radiation.";
RL Gene 378:11-18(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:Q9UI09}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:Q9UI09}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9UI09}; Peripheral membrane protein
CC {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:Q9UI09}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA12 subunit family.
CC {ECO:0000305}.
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DR EMBL; DQ885747; ABH12256.1; -; mRNA.
DR RefSeq; NP_001065252.1; NM_001071784.1.
DR AlphaFoldDB; Q0MQ87; -.
DR SMR; Q0MQ87; -.
DR STRING; 9598.ENSPTRP00000009015; -.
DR PaxDb; Q0MQ87; -.
DR Ensembl; ENSPTRT00000104477; ENSPTRP00000067592; ENSPTRG00000005306.
DR GeneID; 452134; -.
DR KEGG; ptr:452134; -.
DR CTD; 55967; -.
DR VGNC; VGNC:5498; NDUFA12.
DR eggNOG; KOG3382; Eukaryota.
DR GeneTree; ENSGT00390000005848; -.
DR HOGENOM; CLU_110455_1_0_1; -.
DR InParanoid; Q0MQ87; -.
DR OMA; FIWANHK; -.
DR OrthoDB; 1475919at2759; -.
DR TreeFam; TF106106; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000005306; Expressed in heart and 21 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR InterPro; IPR007763; NDUFA12.
DR PANTHER; PTHR12910; PTHR12910; 1.
DR Pfam; PF05071; NDUFA12; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transport.
FT CHAIN 1..145
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 12"
FT /id="PRO_0000251818"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:O97725"
SQ SEQUENCE 145 AA; 17114 MW; C76C7F2F5974AFF9 CRC64;
MELVQVLKRG LQQITGHGGL RGYLRVFFRT NDAKVGTLVG EDKYGNKYYE DNKQFFGRHR
WVVYTTEMNG KNTFWDVDGS MVPPEWHRWL HSMTDDPPTT KPLTARKFIW TNHKFNVTGT
PEQYVPYSTT RKKIQEWIPP STPYK
