ID   NDUAD_MACFA             Reviewed;         163 AA.
AC   Q4R6H1;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13;
DE   AltName: Full=Complex I-B16.6;
DE            Short=CI-B16.6;
DE   AltName: Full=NADH-ubiquinone oxidoreductase B16.6 subunit;
GN   Name=NDUFA13; ORFNames=QtsA-18051;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone. Involved in the
CC       interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This
CC       apoptotic activity is inhibited by interaction with viral IRF1.
CC       Prevents the transactivation of STAT3 target genes. May play a role in
CC       CARD15-mediated innate mucosal responses and serve to regulate
CC       intestinal epithelial cell responses to microbes.
CC       {ECO:0000250|UniProtKB:Q9P0J0}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits. Interacts with
CC       CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1,
CC       STAT2 and STAT5A. Interacts with OLFM4. {ECO:0000250|UniProtKB:Q9P0J0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9P0J0}; Single-pass membrane protein
CC       {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:Q9P0J0}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9P0J0}. Note=Localizes mainly in the
CC       mitochondrion. May be translocated into the nucleus upon IFN/RA
CC       treatment. {ECO:0000250|UniProtKB:Q9P0J0}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA13 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AB169212; BAE01304.1; -; mRNA.
DR   RefSeq; NP_001270819.1; NM_001283890.1.
DR   AlphaFoldDB; Q4R6H1; -.
DR   SMR; Q4R6H1; -.
DR   STRING; 9541.XP_005595352.1; -.
DR   Ensembl; ENSMFAT00000083684; ENSMFAP00000047071; ENSMFAG00000011503.
DR   GeneID; 101926508; -.
DR   CTD; 51079; -.
DR   VEuPathDB; HostDB:ENSMFAG00000045268; -.
DR   eggNOG; KOG3300; Eukaryota.
DR   GeneTree; ENSGT00390000007227; -.
DR   OrthoDB; 1496781at2759; -.
DR   Proteomes; UP000233100; Chromosome 19.
DR   Bgee; ENSMFAG00000011503; Expressed in temporal lobe and 2 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0005746; C:mitochondrial respirasome; ISS:UniProtKB.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0097190; P:apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
DR   GO; GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; ISS:UniProtKB.
DR   InterPro; IPR009346; GRIM-19.
DR   PANTHER; PTHR12966; PTHR12966; 1.
DR   Pfam; PF06212; GRIM-19; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Nucleus; Reference proteome; Respiratory chain; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..163
FT                   /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT                   subunit 13"
FT                   /id="PRO_0000233979"
FT   TRANSMEM        48..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   163 AA;  19018 MW;  D7238949087FC4AA CRC64;
     MAVAVCHFRL GPEVWNTASM EMPKVKQDMP PPGGYGPIDY KRNLPRRGLS GYSMLAIGIG
     TLVYGHWSIM KWNRERRRLQ IEDFEARIAL MPLFQAETDR RTLQMLRENL EEEAIIMKDV
     PDWKVGESVF HTTRWVPPLI GELYGLRTTE ETIHANYGFM WYT