NDUAD_PANTR
ID NDUAD_PANTR Reviewed; 144 AA.
AC Q0MQ90;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13;
DE AltName: Full=Complex I-B16.6;
DE Short=CI-B16.6;
DE AltName: Full=NADH-ubiquinone oxidoreductase B16.6 subunit;
GN Name=NDUFA13;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA Wallace D.C.;
RT "Adaptive selection of mitochondrial complex I subunits during primate
RT radiation.";
RL Gene 378:11-18(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone. Involved in the
CC interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This
CC apoptotic activity is inhibited by interaction with viral IRF1.
CC Prevents the transactivation of STAT3 target genes. May play a role in
CC CARD15-mediated innate mucosal responses and serve to regulate
CC intestinal epithelial cell responses to microbes.
CC {ECO:0000250|UniProtKB:Q9P0J0}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits. Interacts with
CC CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1,
CC STAT2 and STAT5A. Interacts with OLFM4. {ECO:0000250|UniProtKB:Q9P0J0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9P0J0}; Single-pass membrane protein
CC {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:Q9P0J0}. Nucleus
CC {ECO:0000250|UniProtKB:Q9P0J0}. Note=Localizes mainly in the
CC mitochondrion. May be translocated into the nucleus upon IFN/RA
CC treatment. {ECO:0000250|UniProtKB:Q9P0J0}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA13 subunit family.
CC {ECO:0000305}.
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DR EMBL; DQ885744; ABH12253.1; -; mRNA.
DR RefSeq; NP_001065256.1; NM_001071788.1.
DR AlphaFoldDB; Q0MQ90; -.
DR SMR; Q0MQ90; -.
DR STRING; 9598.ENSPTRP00000018326; -.
DR PaxDb; Q0MQ90; -.
DR Ensembl; ENSPTRT00000086775; ENSPTRP00000068091; ENSPTRG00000052571.
DR Ensembl; ENSPTRT00000106024; ENSPTRP00000081122; ENSPTRG00000010741.
DR GeneID; 455877; -.
DR KEGG; ptr:455877; -.
DR CTD; 51079; -.
DR VGNC; VGNC:6639; NDUFA13.
DR eggNOG; KOG3300; Eukaryota.
DR GeneTree; ENSGT00390000000719; -.
DR HOGENOM; CLU_119720_0_0_1; -.
DR InParanoid; Q0MQ90; -.
DR OrthoDB; 1496781at2759; -.
DR TreeFam; TF315182; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000010741; Expressed in Brodmann (1909) area 10 and 21 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR GO; GO:0005746; C:mitochondrial respirasome; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0097190; P:apoptotic signaling pathway; ISS:UniProtKB.
DR GO; GO:0035458; P:cellular response to interferon-beta; IEA:Ensembl.
DR GO; GO:0071300; P:cellular response to retinoic acid; IEA:Ensembl.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
DR GO; GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0072593; P:reactive oxygen species metabolic process; ISS:UniProtKB.
DR InterPro; IPR009346; GRIM-19.
DR PANTHER; PTHR12966; PTHR12966; 1.
DR Pfam; PF06212; GRIM-19; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Nucleus; Reference proteome;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q95KV7"
FT CHAIN 2..144
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 13"
FT /id="PRO_0000251821"
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q95KV7"
SQ SEQUENCE 144 AA; 16728 MW; 12BF608B235FF856 CRC64;
MAASKVKQDM PPPGGYGPID YKRNLPRRGL SGYSMLAIGI GTLIYGHWSI MKWNRERRRL
QIEDFEARIA LLPLLQAETD RRTLQMLREN LEEEAIIMKD VPDWKVGESV FHTTRWVPPL
IGELYGLRTT EEALHASHGF MWYM
