NDUB1_BOVIN
ID NDUB1_BOVIN Reviewed; 57 AA.
AC Q02378;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1;
DE AltName: Full=Complex I-MNLL;
DE Short=CI-MNLL;
DE AltName: Full=NADH-ubiquinone oxidoreductase MNLL subunit;
GN Name=NDUFB1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 1-27; 29-30 AND 32-34.
RC TISSUE=Heart;
RX PubMed=1518044; DOI=10.1016/0022-2836(92)91052-q;
RA Walker J.E., Arizmendi J.M., Dupuis A., Fearnley I.M., Finel M., Medd S.M.,
RA Pilkington S.J., Runswick M.J., Skehel J.M.;
RT "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine
RT heart mitochondria. Application of a novel strategy for sequencing proteins
RT using the polymerase chain reaction.";
RL J. Mol. Biol. 226:1051-1072(1992).
RN [2]
RP PARTIAL PROTEIN SEQUENCE, SUBUNIT, IDENTIFICATION IN COMPLEX I, AND
RP SUBCELLULAR LOCATION.
RX PubMed=10852722; DOI=10.1021/bi000335t;
RA Sazanov L.A., Peak-Chew S.Y., Fearnley I.M., Walker J.E.;
RT "Resolution of the membrane domain of bovine complex I into subcomplexes:
RT implications for the structural organization of the enzyme.";
RL Biochemistry 39:7229-7235(2000).
RN [3]
RP SUBUNIT, IDENTIFICATION IN COMPLEX I, AND SUBCELLULAR LOCATION.
RX PubMed=18721790; DOI=10.1016/j.ab.2008.07.029;
RA Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A.,
RA Robinson N.C.;
RT "Subunit analysis of bovine heart complex I by reversed-phase high-
RT performance liquid chromatography, electrospray ionization-tandem mass
RT spectrometry, and matrix-assisted laser desorption/ionization-time-of-
RT flight mass spectrometry.";
RL Anal. Biochem. 382:116-121(2008).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I) that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O75438}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000269|PubMed:10852722, ECO:0000269|PubMed:1518044,
CC ECO:0000269|PubMed:18721790}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000305|PubMed:10852722, ECO:0000305|PubMed:18721790}; Single-pass
CC membrane protein {ECO:0000255}; Matrix side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB1 subunit family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA44908.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X63223; CAA44908.1; ALT_INIT; mRNA.
DR PIR; S28251; S28251.
DR RefSeq; NP_787003.1; NM_175809.2.
DR PDB; 5LC5; EM; 4.35 A; f=1-57.
DR PDB; 5LDW; EM; 4.27 A; f=1-57.
DR PDB; 5LDX; EM; 5.60 A; f=1-57.
DR PDB; 5O31; EM; 4.13 A; f=1-57.
DR PDB; 7QSD; EM; 3.10 A; f=1-57.
DR PDBsum; 5LC5; -.
DR PDBsum; 5LDW; -.
DR PDBsum; 5LDX; -.
DR PDBsum; 5O31; -.
DR PDBsum; 7QSD; -.
DR AlphaFoldDB; Q02378; -.
DR SMR; Q02378; -.
DR CORUM; Q02378; -.
DR DIP; DIP-38823N; -.
DR IntAct; Q02378; 2.
DR STRING; 9913.ENSBTAP00000020160; -.
DR TCDB; 3.D.1.6.1; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR PaxDb; Q02378; -.
DR PRIDE; Q02378; -.
DR GeneID; 327690; -.
DR KEGG; bta:327690; -.
DR CTD; 4707; -.
DR eggNOG; ENOG502S6X0; Eukaryota.
DR HOGENOM; CLU_208707_0_0_1; -.
DR InParanoid; Q02378; -.
DR OMA; SSVNWAH; -.
DR OrthoDB; 1603177at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR012575; NDUB1.
DR PANTHER; PTHR15222; PTHR15222; 1.
DR Pfam; PF08040; NADH_oxidored; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Electron transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..57
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 1"
FT /id="PRO_0000118826"
FT TRANSMEM 10..26
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 57 AA; 6966 MW; 56D0A3C8CB046973 CRC64;
MNLLQVVRDH WVHVLVPMGF VFGYYLDRKN DEKLTAFRNK SLLYKRELKP NEEVTWK
