NDUB1_MOUSE
ID NDUB1_MOUSE Reviewed; 57 AA.
AC P0DN34;
DT 09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT 09-DEC-2015, sequence version 1.
DT 03-AUG-2022, entry version 30.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1;
DE AltName: Full=Complex I-MNLL;
DE Short=CI-MNLL;
DE AltName: Full=NADH-ubiquinone oxidoreductase MNLL subunit;
GN Name=Ndufb1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I) that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O75438}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O75438}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O75438}; Single-pass membrane protein
CC {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O75438}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB1 subunit family.
CC {ECO:0000305}.
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DR EMBL; AC121965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PDB; 6G2J; EM; 3.30 A; f=1-57.
DR PDB; 6G72; EM; 3.90 A; f=1-57.
DR PDB; 6ZR2; EM; 3.10 A; f=1-57.
DR PDB; 6ZTQ; EM; 3.00 A; f=1-57.
DR PDB; 7AK5; EM; 3.17 A; f=1-57.
DR PDB; 7AK6; EM; 3.82 A; f=1-57.
DR PDB; 7B93; EM; 3.04 A; f=1-57.
DR PDB; 7PSA; EM; 3.40 A; f=1-57.
DR PDBsum; 6G2J; -.
DR PDBsum; 6G72; -.
DR PDBsum; 6ZR2; -.
DR PDBsum; 6ZTQ; -.
DR PDBsum; 7AK5; -.
DR PDBsum; 7AK6; -.
DR PDBsum; 7B93; -.
DR PDBsum; 7PSA; -.
DR AlphaFoldDB; P0DN34; -.
DR SMR; P0DN34; -.
DR ComplexPortal; CPX-266; Mitochondrial respiratory chain complex I.
DR IntAct; P0DN34; 1.
DR PhosphoSitePlus; P0DN34; -.
DR jPOST; P0DN34; -.
DR PRIDE; P0DN34; -.
DR ProteomicsDB; 252940; -.
DR Antibodypedia; 26722; 94 antibodies from 24 providers.
DR Ensembl; ENSMUST00000221191; ENSMUSP00000159028; ENSMUSG00000113902.
DR Ensembl; ENSMUST00000221227; ENSMUSP00000158975; ENSMUSG00000113902.
DR Ensembl; ENSMUST00000221422; ENSMUSP00000159138; ENSMUSG00000113902.
DR MGI; MGI:3780865; Ndufb1.
DR VEuPathDB; HostDB:ENSMUSG00000113902; -.
DR GeneTree; ENSGT00390000005052; -.
DR OMA; AREHWVN; -.
DR PRO; PR:P0DN34; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; P0DN34; protein.
DR Bgee; ENSMUSG00000113902; Expressed in right kidney and 138 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0009060; P:aerobic respiration; IC:ComplexPortal.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR GO; GO:0042776; P:proton motive force-driven mitochondrial ATP synthesis; IC:ComplexPortal.
DR InterPro; IPR012575; NDUB1.
DR PANTHER; PTHR15222; PTHR15222; 1.
DR Pfam; PF08040; NADH_oxidored; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..57
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 1"
FT /id="PRO_0000434810"
FT TRANSMEM 10..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 4..7
FT /evidence="ECO:0007829|PDB:7B93"
FT TURN 8..10
FT /evidence="ECO:0007829|PDB:7B93"
FT HELIX 11..14
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 15..33
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT TURN 38..40
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT TURN 42..44
FT /evidence="ECO:0007829|PDB:7B93"
SQ SEQUENCE 57 AA; 6954 MW; EC793021C24CFE65 CRC64;
MTLFQLLREH WVHILVPAGF VFGCYLDRKD DEKLTAFRNK SMLFQRELRP NEEVTWK
