NDUB3_GORGO
ID NDUB3_GORGO Reviewed; 98 AA.
AC Q0MQD1;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3;
DE AltName: Full=Complex I-B12;
DE Short=CI-B12;
DE AltName: Full=NADH-ubiquinone oxidoreductase B12 subunit;
GN Name=NDUFB3;
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA Wallace D.C.;
RT "Adaptive selection of mitochondrial complex I subunits during primate
RT radiation.";
RL Gene 378:11-18(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O43676}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O43676}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O43676}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:O43676}; Matrix side
CC {ECO:0000250|UniProtKB:O43676}.
CC -!- PTM: Methylation at His residues by METTL9 enhances complex I-mediated
CC mitochondrial respiration. {ECO:0000250|UniProtKB:O43676}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB3 subunit family.
CC {ECO:0000305}.
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DR EMBL; DQ885703; ABH12212.1; -; mRNA.
DR RefSeq; NP_001266646.1; NM_001279717.1.
DR RefSeq; XP_018877155.1; XM_019021610.1.
DR RefSeq; XP_018877156.1; XM_019021611.1.
DR AlphaFoldDB; Q0MQD1; -.
DR SMR; Q0MQD1; -.
DR STRING; 9593.ENSGGOP00000017605; -.
DR Ensembl; ENSGGOT00000025368; ENSGGOP00000017605; ENSGGOG00000023537.
DR GeneID; 101132493; -.
DR KEGG; ggo:101132493; -.
DR CTD; 4709; -.
DR eggNOG; KOG4631; Eukaryota.
DR GeneTree; ENSGT00390000010316; -.
DR HOGENOM; CLU_160226_1_0_1; -.
DR InParanoid; Q0MQD1; -.
DR OMA; EAWRYEP; -.
DR OrthoDB; 1568057at2759; -.
DR Proteomes; UP000001519; Chromosome 2B.
DR Bgee; ENSGGOG00000023537; Expressed in heart and 6 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR012576; NDUFB3.
DR PANTHER; PTHR15082; PTHR15082; 1.
DR Pfam; PF08122; NDUF_B12; 1.
PE 3: Inferred from homology;
KW Acetylation; Electron transport; Membrane; Methylation; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q02365"
FT CHAIN 2..98
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 3"
FT /id="PRO_0000251828"
FT TRANSMEM 66..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q02365"
FT MOD_RES 5
FT /note="Pros-methylhistidine"
FT /evidence="ECO:0000250|UniProtKB:O43676"
FT MOD_RES 7
FT /note="Pros-methylhistidine"
FT /evidence="ECO:0000250|UniProtKB:O43676"
FT MOD_RES 9
FT /note="Pros-methylhistidine"
FT /evidence="ECO:0000250|UniProtKB:O43676"
FT MOD_RES 23
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9CQZ6"
FT MOD_RES 23
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9CQZ6"
FT MOD_RES 34
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9CQZ6"
FT MOD_RES 34
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9CQZ6"
SQ SEQUENCE 98 AA; 11402 MW; 1C77F0C7A4DC757F CRC64;
MAHEHGHEHG HHKMELPDYR QWKIEGTPLE TIQKKLAAKG LRDPWGRNEA WRYMGGFAKS
VSFSDVFFKG FKWGFAAFVV AVGAEYYLES LNKDKKHH
