ID   NDUB3_PANTR             Reviewed;          98 AA.
AC   Q0MQD2;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3;
DE   AltName: Full=Complex I-B12;
DE            Short=CI-B12;
DE   AltName: Full=NADH-ubiquinone oxidoreductase B12 subunit;
GN   Name=NDUFB3;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA   Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA   Wallace D.C.;
RT   "Adaptive selection of mitochondrial complex I subunits during primate
RT   radiation.";
RL   Gene 378:11-18(2006).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O43676}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:O43676}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O43676}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:O43676}; Matrix side
CC       {ECO:0000250|UniProtKB:O43676}.
CC   -!- PTM: Methylation at His residues by METTL9 enhances complex I-mediated
CC       mitochondrial respiration. {ECO:0000250|UniProtKB:O43676}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFB3 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; DQ885702; ABH12211.1; -; mRNA.
DR   RefSeq; NP_001070251.1; NM_001076783.1.
DR   RefSeq; XP_009441969.1; XM_009443694.1.
DR   RefSeq; XP_016804830.1; XM_016949341.1.
DR   AlphaFoldDB; Q0MQD2; -.
DR   SMR; Q0MQD2; -.
DR   STRING; 9598.ENSPTRP00000021865; -.
DR   PaxDb; Q0MQD2; -.
DR   Ensembl; ENSPTRT00000023711; ENSPTRP00000021865; ENSPTRG00000012797.
DR   GeneID; 459871; -.
DR   KEGG; ptr:459871; -.
DR   CTD; 4709; -.
DR   VGNC; VGNC:6111; NDUFB3.
DR   eggNOG; KOG4631; Eukaryota.
DR   GeneTree; ENSGT00390000010316; -.
DR   HOGENOM; CLU_160226_1_0_1; -.
DR   InParanoid; Q0MQD2; -.
DR   OMA; EAWRYEP; -.
DR   OrthoDB; 1568057at2759; -.
DR   TreeFam; TF319656; -.
DR   Proteomes; UP000002277; Chromosome 2B.
DR   Bgee; ENSPTRG00000012797; Expressed in heart and 21 other tissues.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR012576; NDUFB3.
DR   PANTHER; PTHR15082; PTHR15082; 1.
DR   Pfam; PF08122; NDUF_B12; 1.
PE   3: Inferred from homology;
KW   Acetylation; Electron transport; Membrane; Methylation; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW   Transmembrane; Transmembrane helix; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q02365"
FT   CHAIN           2..98
FT                   /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT                   subunit 3"
FT                   /id="PRO_0000251829"
FT   TRANSMEM        66..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q02365"
FT   MOD_RES         5
FT                   /note="Pros-methylhistidine"
FT                   /evidence="ECO:0000250|UniProtKB:O43676"
FT   MOD_RES         7
FT                   /note="Pros-methylhistidine"
FT                   /evidence="ECO:0000250|UniProtKB:O43676"
FT   MOD_RES         9
FT                   /note="Pros-methylhistidine"
FT                   /evidence="ECO:0000250|UniProtKB:O43676"
FT   MOD_RES         23
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CQZ6"
FT   MOD_RES         23
FT                   /note="N6-succinyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CQZ6"
FT   MOD_RES         34
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CQZ6"
FT   MOD_RES         34
FT                   /note="N6-succinyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CQZ6"
SQ   SEQUENCE   98 AA;  11402 MW;  1C77F0C7A4DC757F CRC64;
     MAHEHGHEHG HHKMELPDYR QWKIEGTPLE TIQKKLAAKG LRDPWGRNEA WRYMGGFAKS
     VSFSDVFFKG FKWGFAAFVV AVGAEYYLES LNKDKKHH