ID   NDUB3_PONPY             Reviewed;          94 AA.
AC   Q0MQD0;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3;
DE   AltName: Full=Complex I-B12;
DE            Short=CI-B12;
DE   AltName: Full=NADH-ubiquinone oxidoreductase B12 subunit;
GN   Name=NDUFB3;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA   Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA   Wallace D.C.;
RT   "Adaptive selection of mitochondrial complex I subunits during primate
RT   radiation.";
RL   Gene 378:11-18(2006).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O43676}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:O43676}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O43676}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:O43676}; Matrix side
CC       {ECO:0000250|UniProtKB:O43676}.
CC   -!- PTM: Methylation at His residues by METTL9 enhances complex I-mediated
CC       mitochondrial respiration. {ECO:0000250|UniProtKB:O43676}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFB3 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; DQ885704; ABH12213.1; -; mRNA.
DR   AlphaFoldDB; Q0MQD0; -.
DR   SMR; Q0MQD0; -.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR012576; NDUFB3.
DR   PANTHER; PTHR15082; PTHR15082; 1.
DR   Pfam; PF08122; NDUF_B12; 1.
PE   3: Inferred from homology;
KW   Acetylation; Electron transport; Membrane; Methylation; Mitochondrion;
KW   Mitochondrion inner membrane; Respiratory chain; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..94
FT                   /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT                   subunit 3"
FT                   /id="PRO_0000251830"
FT   TRANSMEM        62..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         3
FT                   /note="Pros-methylhistidine"
FT                   /evidence="ECO:0000250|UniProtKB:O43676"
FT   MOD_RES         5
FT                   /note="Pros-methylhistidine"
FT                   /evidence="ECO:0000250|UniProtKB:O43676"
FT   MOD_RES         19
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CQZ6"
FT   MOD_RES         19
FT                   /note="N6-succinyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CQZ6"
FT   MOD_RES         30
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CQZ6"
FT   MOD_RES         30
FT                   /note="N6-succinyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CQZ6"
SQ   SEQUENCE   94 AA;  11003 MW;  240D161E9D946E28 CRC64;
     MAHEHGHHKM ELPDYKQWKI EGTPLETIQK KLAAKGLRDP WGRNEAWRYM GGFTKSVSFF
     DVFFKGFKWG FAAFVVAVGA EYYLKSLNKD KKHH