NDUB4_CHICK
ID NDUB4_CHICK Reviewed; 133 AA.
AC P48306;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4;
DE AltName: Full=Complex I-B15;
DE Short=CI-B15;
DE AltName: Full=GGHPW;
DE AltName: Full=NADH-ubiquinone oxidoreductase B15 subunit;
DE AltName: Full=Protein Walter;
GN Name=NDUFB4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7901127; DOI=10.1016/0378-1119(93)90644-i;
RA Goldberg G.S., Kaczmarczyk W.;
RT "A chicken genomic DNA fragment that hybridizes to the murine Hox-3.1
RT homeobox is likely to encode the NADH ubiquinone oxidoreductase subunit
RT B15.";
RL Gene 133:233-235(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1359990; DOI=10.1016/0378-1119(92)90151-e;
RA Goldberg G.S., Kaczmarczyk W.;
RT "Sequence of a novel chicken genomic DNA fragment that hybridizes to the
RT murine Hox-3.1 homeobox.";
RL Gene 121:397-398(1992).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O95168}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O95168}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O95168}; Single-pass membrane protein
CC {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O95168}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB4 subunit family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA70193.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAA43193.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X60778; CAA43193.1; ALT_SEQ; Genomic_DNA.
DR EMBL; M84354; AAA70193.1; ALT_SEQ; Genomic_DNA.
DR PIR; A33164; A33164.
DR PIR; JC2003; JC2003.
DR AlphaFoldDB; P48306; -.
DR SMR; P48306; -.
DR STRING; 9031.ENSGALP00000042287; -.
DR PaxDb; P48306; -.
DR VEuPathDB; HostDB:geneid_769954; -.
DR eggNOG; ENOG502S2HF; Eukaryota.
DR InParanoid; P48306; -.
DR PhylomeDB; P48306; -.
DR PRO; PR:P48306; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR009866; NADH_UbQ_OxRdtase_NDUFB4_su.
DR PANTHER; PTHR15469; PTHR15469; 1.
DR Pfam; PF07225; NDUF_B4; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Respiratory chain; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..133
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 4"
FT /id="PRO_0000118802"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 133 AA; 14938 MW; ED7E82948C97B352 CRC64;
MASGPSRTAA EEYRPNRYVS LPAELDPATY DTPLEKRRAE AERLAIRARL KRQYLLQLNT
PKPPRVIEDP ALLRWDYART HNVYPTFRPT PKTSFLGAVF AIGPILFWIA AFKTERVSSA
GGVEHQGAPG CKT
