NDUB4_PANTR
ID NDUB4_PANTR Reviewed; 129 AA.
AC Q0MQD5;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4;
DE AltName: Full=Complex I-B15;
DE Short=CI-B15;
DE AltName: Full=NADH-ubiquinone oxidoreductase B15 subunit;
GN Name=NDUFB4;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA Wallace D.C.;
RT "Adaptive selection of mitochondrial complex I subunits during primate
RT radiation.";
RL Gene 378:11-18(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O95168}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O95168}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O95168}; Single-pass membrane protein
CC {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O95168}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB4 subunit family.
CC {ECO:0000305}.
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DR EMBL; DQ885699; ABH12208.1; -; mRNA.
DR RefSeq; NP_001065260.1; NM_001071792.1.
DR AlphaFoldDB; Q0MQD5; -.
DR SMR; Q0MQD5; -.
DR STRING; 9598.ENSPTRP00000026324; -.
DR PaxDb; Q0MQD5; -.
DR Ensembl; ENSPTRT00000028523; ENSPTRP00000026324; ENSPTRG00000015270.
DR GeneID; 460612; -.
DR KEGG; ptr:460612; -.
DR CTD; 4710; -.
DR VGNC; VGNC:7988; NDUFB4.
DR eggNOG; ENOG502S2HF; Eukaryota.
DR GeneTree; ENSGT00390000007133; -.
DR HOGENOM; CLU_123402_0_0_1; -.
DR InParanoid; Q0MQD5; -.
DR OMA; PLFFWFY; -.
DR OrthoDB; 1434967at2759; -.
DR TreeFam; TF328761; -.
DR Proteomes; UP000002277; Chromosome 3.
DR Bgee; ENSPTRG00000015270; Expressed in heart and 21 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
DR InterPro; IPR009866; NADH_UbQ_OxRdtase_NDUFB4_su.
DR PANTHER; PTHR15469; PTHR15469; 1.
DR Pfam; PF07225; NDUF_B4; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Phosphoprotein; Reference proteome;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P48305"
FT CHAIN 2..129
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 4"
FT /id="PRO_0000251832"
FT TRANSMEM 88..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P48305"
FT MOD_RES 26
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O95168"
SQ SEQUENCE 129 AA; 15209 MW; E5060D0BF46FFF28 CRC64;
MSFPKYKPSS LRTLPETLDP AEYNISPETR RAQAERLAIR AQLKREYLLQ YNDPNRRGLI
ENPALLRWAY ARTINVYPNF RPTPKNSLMG ALCGFGPLIF IYYIIKTERD RKEKLIQEGK
LDRTFHLSY
