NDUB5_MACFA
ID NDUB5_MACFA Reviewed; 189 AA.
AC Q4R4E0;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial;
DE AltName: Full=Complex I-SGDH;
DE Short=CI-SGDH;
DE AltName: Full=NADH-ubiquinone oxidoreductase SGDH subunit;
DE Flags: Precursor;
GN Name=NDUFB5; ORFNames=QtsA-10659;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O43674}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O43674}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O43674}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:O43674}; Matrix side
CC {ECO:0000250|UniProtKB:O43674}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB5 subunit family.
CC {ECO:0000305}.
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DR EMBL; AB178974; BAE02025.1; -; mRNA.
DR RefSeq; NP_001270530.1; NM_001283601.1.
DR AlphaFoldDB; Q4R4E0; -.
DR SMR; Q4R4E0; -.
DR STRING; 9541.XP_005546499.1; -.
DR Ensembl; ENSMFAT00000004233; ENSMFAP00000030028; ENSMFAG00000042220.
DR GeneID; 101866824; -.
DR CTD; 4711; -.
DR VEuPathDB; HostDB:ENSMFAG00000042220; -.
DR eggNOG; KOG4632; Eukaryota.
DR GeneTree; ENSGT00390000009980; -.
DR OMA; DYQAYYY; -.
DR OrthoDB; 1251699at2759; -.
DR Proteomes; UP000233100; Chromosome 2.
DR Bgee; ENSMFAG00000042220; Expressed in heart and 13 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR019173; NADH_UbQ_OxRdtase_B5_su.
DR PANTHER; PTHR13178; PTHR13178; 1.
DR Pfam; PF09781; NDUF_B5; 1.
PE 2: Evidence at transcript level;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Respiratory chain; Transit peptide; Transmembrane;
KW Transmembrane helix; Transport.
FT TRANSIT 1..46
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 47..189
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 5, mitochondrial"
FT /id="PRO_0000233983"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 189 AA; 21685 MW; 71010A1767E4962A CRC64;
MAGMSLLRRV SVTAVAALSG RSLGTRLGFG GFLTRGFPKA VAPVRHSGGH GKRLFVIKPS
RFYDIRFLKL LRFYIALTGI PVVIIITLVN VFIGEAELAE IPEGYIPEHW EYYKHPISRW
IARNFYDSPE KIYEKSMAVL QIEAEKAELR LKELEVRRLM RMRGDGPWYY YETIDKELID
HSPKATPDN
