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NDUB5_MOUSE
ID   NDUB5_MOUSE             Reviewed;         189 AA.
AC   Q9CQH3;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial;
DE   AltName: Full=Complex I-SGDH;
DE            Short=CI-SGDH;
DE   AltName: Full=NADH-ubiquinone oxidoreductase SGDH subunit;
DE   Flags: Precursor;
GN   Name=Ndufb5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Colon, and Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 54-66; 124-131; 136-150 AND 161-176, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY.
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RA   Lubec G., Kang S.U.;
RL   Submitted (APR-2007) to UniProtKB.
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC   Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O43674}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:O43674}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O43674}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:O43674}; Matrix side
CC       {ECO:0000250|UniProtKB:O43674}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFB5 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AK018562; BAB31277.1; -; mRNA.
DR   EMBL; AK004372; BAB23279.1; -; mRNA.
DR   EMBL; AK013223; BAB28724.1; -; mRNA.
DR   EMBL; BC025155; AAH25155.1; -; mRNA.
DR   CCDS; CCDS17300.1; -.
DR   RefSeq; NP_079592.2; NM_025316.2.
DR   PDB; 6G2J; EM; 3.30 A; h=1-189.
DR   PDB; 6G72; EM; 3.90 A; h=1-189.
DR   PDB; 6ZR2; EM; 3.10 A; h=1-189.
DR   PDB; 6ZTQ; EM; 3.00 A; h=1-189.
DR   PDB; 7AK5; EM; 3.17 A; h=1-189.
DR   PDB; 7AK6; EM; 3.82 A; h=1-189.
DR   PDB; 7B93; EM; 3.04 A; h=1-189.
DR   PDB; 7PSA; EM; 3.40 A; h=1-189.
DR   PDBsum; 6G2J; -.
DR   PDBsum; 6G72; -.
DR   PDBsum; 6ZR2; -.
DR   PDBsum; 6ZTQ; -.
DR   PDBsum; 7AK5; -.
DR   PDBsum; 7AK6; -.
DR   PDBsum; 7B93; -.
DR   PDBsum; 7PSA; -.
DR   AlphaFoldDB; Q9CQH3; -.
DR   SMR; Q9CQH3; -.
DR   BioGRID; 211174; 36.
DR   ComplexPortal; CPX-266; Mitochondrial respiratory chain complex I.
DR   CORUM; Q9CQH3; -.
DR   IntAct; Q9CQH3; 4.
DR   STRING; 10090.ENSMUSP00000114963; -.
DR   iPTMnet; Q9CQH3; -.
DR   PhosphoSitePlus; Q9CQH3; -.
DR   EPD; Q9CQH3; -.
DR   jPOST; Q9CQH3; -.
DR   MaxQB; Q9CQH3; -.
DR   PaxDb; Q9CQH3; -.
DR   PeptideAtlas; Q9CQH3; -.
DR   PRIDE; Q9CQH3; -.
DR   ProteomicsDB; 252867; -.
DR   DNASU; 66046; -.
DR   Ensembl; ENSMUST00000127477; ENSMUSP00000114963; ENSMUSG00000027673.
DR   GeneID; 66046; -.
DR   KEGG; mmu:66046; -.
DR   UCSC; uc008owq.1; mouse.
DR   CTD; 4711; -.
DR   MGI; MGI:1913296; Ndufb5.
DR   VEuPathDB; HostDB:ENSMUSG00000027673; -.
DR   eggNOG; KOG4632; Eukaryota.
DR   GeneTree; ENSGT00390000009980; -.
DR   HOGENOM; CLU_100260_2_0_1; -.
DR   InParanoid; Q9CQH3; -.
DR   OMA; DYQAYYY; -.
DR   OrthoDB; 1251699at2759; -.
DR   PhylomeDB; Q9CQH3; -.
DR   TreeFam; TF313997; -.
DR   Reactome; R-MMU-611105; Respiratory electron transport.
DR   Reactome; R-MMU-6799198; Complex I biogenesis.
DR   BioGRID-ORCS; 66046; 18 hits in 74 CRISPR screens.
DR   ChiTaRS; Ndufb5; mouse.
DR   PRO; PR:Q9CQH3; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q9CQH3; protein.
DR   Bgee; ENSMUSG00000027673; Expressed in plantaris and 257 other tissues.
DR   ExpressionAtlas; Q9CQH3; baseline and differential.
DR   Genevisible; Q9CQH3; MM.
DR   GO; GO:0005743; C:mitochondrial inner membrane; HDA:MGI.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0009060; P:aerobic respiration; IC:ComplexPortal.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   GO; GO:0042776; P:proton motive force-driven mitochondrial ATP synthesis; IC:ComplexPortal.
DR   InterPro; IPR019173; NADH_UbQ_OxRdtase_B5_su.
DR   PANTHER; PTHR13178; PTHR13178; 1.
DR   Pfam; PF09781; NDUF_B5; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Electron transport; Membrane;
KW   Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Respiratory chain; Transit peptide; Transmembrane; Transmembrane helix;
KW   Transport.
FT   TRANSIT         1..46
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           47..189
FT                   /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT                   subunit 5, mitochondrial"
FT                   /id="PRO_0000020053"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   HELIX           63..92
FT                   /evidence="ECO:0007829|PDB:6ZTQ"
FT   HELIX           109..112
FT                   /evidence="ECO:0007829|PDB:6ZTQ"
FT   HELIX           116..125
FT                   /evidence="ECO:0007829|PDB:6ZTQ"
FT   HELIX           129..162
FT                   /evidence="ECO:0007829|PDB:6ZTQ"
FT   STRAND          166..169
FT                   /evidence="ECO:0007829|PDB:7B93"
FT   HELIX           176..178
FT                   /evidence="ECO:0007829|PDB:7AK5"
FT   STRAND          185..187
FT                   /evidence="ECO:0007829|PDB:6ZTQ"
SQ   SEQUENCE   189 AA;  21710 MW;  8D998EA6CD683DE3 CRC64;
     MAAMSLLQRA SVSALTALSC RRAGPRLGVG SFLTRSFPKT VAPVRHSGDH GKRLFVVKPS
     LYYDARFLRL MKFYLMLTGI PVIIGITLVN IFIGEAELAE IPEGYIPEHW EYYKHPISRW
     IARNFYDGPE KNYEKTLAIL QIESEKAELR LKEQEVRRLM RARGDGPWYQ FPTPEKEFID
     HSPKATPDN
 
 
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