NDUB5_PANTR
ID NDUB5_PANTR Reviewed; 189 AA.
AC Q0MQD8;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial;
DE AltName: Full=Complex I-SGDH;
DE Short=CI-SGDH;
DE AltName: Full=NADH-ubiquinone oxidoreductase SGDH subunit;
DE Flags: Precursor;
GN Name=NDUFB5;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA Wallace D.C.;
RT "Adaptive selection of mitochondrial complex I subunits during primate
RT radiation.";
RL Gene 378:11-18(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O43674}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O43674}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O43674}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:O43674}; Matrix side
CC {ECO:0000250|UniProtKB:O43674}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB5 subunit family.
CC {ECO:0000305}.
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DR EMBL; DQ885696; ABH12205.1; -; mRNA.
DR RefSeq; NP_001065274.1; NM_001071806.1.
DR AlphaFoldDB; Q0MQD8; -.
DR SMR; Q0MQD8; -.
DR STRING; 9598.ENSPTRP00000026930; -.
DR PaxDb; Q0MQD8; -.
DR Ensembl; ENSPTRT00000080382; ENSPTRP00000084075; ENSPTRG00000015649.
DR GeneID; 471008; -.
DR KEGG; ptr:471008; -.
DR CTD; 4711; -.
DR VGNC; VGNC:7989; NDUFB5.
DR eggNOG; KOG4632; Eukaryota.
DR GeneTree; ENSGT00390000009980; -.
DR HOGENOM; CLU_100260_2_0_1; -.
DR InParanoid; Q0MQD8; -.
DR OMA; DYQAYYY; -.
DR OrthoDB; 1251699at2759; -.
DR TreeFam; TF313997; -.
DR Proteomes; UP000002277; Chromosome 3.
DR Bgee; ENSPTRG00000015649; Expressed in skeletal muscle tissue and 21 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR019173; NADH_UbQ_OxRdtase_B5_su.
DR PANTHER; PTHR13178; PTHR13178; 1.
DR Pfam; PF09781; NDUF_B5; 1.
PE 2: Evidence at transcript level;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Respiratory chain; Transit peptide; Transmembrane;
KW Transmembrane helix; Transport.
FT TRANSIT 1..46
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 47..189
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 5, mitochondrial"
FT /id="PRO_0000251834"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 189 AA; 21750 MW; 66D288F7AB7FD5C5 CRC64;
MAAMSLLRRV SVTAVAALSG RPLGTRLGFG GFLTRGFPKA AAPVRHSGDH GKRLFVIRPS
RFYDRRFLKL LRFYIALTGI PVAIFITLVN VFIGQAELAE IPEGYVPEHW EYYKHPISRW
IARNFYDSPE KIYERTMAVL QIEAEKAELR VKELEVRKLM HVRGDGPWYY YETIDKELID
HSPKATPDN
