NDUB5_PONPY
ID NDUB5_PONPY Reviewed; 189 AA.
AC Q0MQD6;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial;
DE AltName: Full=Complex I-SGDH;
DE Short=CI-SGDH;
DE AltName: Full=NADH-ubiquinone oxidoreductase SGDH subunit;
DE Flags: Precursor;
GN Name=NDUFB5;
OS Pongo pygmaeus (Bornean orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA Wallace D.C.;
RT "Adaptive selection of mitochondrial complex I subunits during primate
RT radiation.";
RL Gene 378:11-18(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O43674}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O43674}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O43674}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:O43674}; Matrix side
CC {ECO:0000250|UniProtKB:O43674}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB5 subunit family.
CC {ECO:0000305}.
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DR EMBL; DQ885698; ABH12207.1; -; mRNA.
DR AlphaFoldDB; Q0MQD6; -.
DR SMR; Q0MQD6; -.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR019173; NADH_UbQ_OxRdtase_B5_su.
DR PANTHER; PTHR13178; PTHR13178; 1.
DR Pfam; PF09781; NDUF_B5; 1.
PE 2: Evidence at transcript level;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Respiratory chain; Transit peptide; Transmembrane; Transmembrane helix;
KW Transport.
FT TRANSIT 1..46
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 47..189
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 5, mitochondrial"
FT /id="PRO_0000251835"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 189 AA; 21774 MW; FBEF8E5A0028CA4A CRC64;
MAAMSLLRRV SVTAVAALSG RPLGTRLGFG GFLTRGFPKA AAPVRHSGAH GKRLFFIRPS
RFYDRRFLKL LRFYIALTGI PVAIFITLVN VFIGQAELAE IPEGYIPEHW EYYKHPISRW
IARNFYDSPE KIYERTMAVL QIEAETAELR LKELEVRKLM RVRGDGPWYY YETIDKELID
HSPKATPDN