NDUB6_GORGO
ID NDUB6_GORGO Reviewed; 128 AA.
AC Q0MQE0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6;
DE AltName: Full=Complex I-B17;
DE Short=CI-B17;
DE AltName: Full=NADH-ubiquinone oxidoreductase B17 subunit;
GN Name=NDUFB6;
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA Wallace D.C.;
RT "Adaptive selection of mitochondrial complex I subunits during primate
RT radiation.";
RL Gene 378:11-18(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O95139}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O95139}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O95139}; Single-pass membrane protein
CC {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O95139}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB6 subunit family.
CC {ECO:0000305}.
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DR EMBL; DQ885694; ABH12203.1; -; mRNA.
DR RefSeq; NP_001266692.1; NM_001279763.1.
DR AlphaFoldDB; Q0MQE0; -.
DR SMR; Q0MQE0; -.
DR STRING; 9593.ENSGGOP00000010000; -.
DR Ensembl; ENSGGOT00000064183; ENSGGOP00000051550; ENSGGOG00000010253.
DR GeneID; 101133566; -.
DR KEGG; ggo:101133566; -.
DR CTD; 4712; -.
DR eggNOG; KOG4633; Eukaryota.
DR GeneTree; ENSGT00390000007535; -.
DR HOGENOM; CLU_171928_0_0_1; -.
DR InParanoid; Q0MQE0; -.
DR OMA; KYHVNTK; -.
DR OrthoDB; 1545413at2759; -.
DR Proteomes; UP000001519; Chromosome 9.
DR Bgee; ENSGGOG00000010253; Expressed in heart and 6 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR019174; NADH_DH_b-subcmplx_su6.
DR PANTHER; PTHR15083; PTHR15083; 1.
DR Pfam; PF09782; NDUF_B6; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O95139"
FT CHAIN 2..128
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 6"
FT /id="PRO_0000251836"
FT TRANSMEM 68..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylthreonine"
FT /evidence="ECO:0000250|UniProtKB:O95139"
FT MOD_RES 24
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q3UIU2"
SQ SEQUENCE 128 AA; 15489 MW; E8E1EC15EB155711 CRC64;
MTGYTPDEKL RLQQLRELRR RWLKDQELSP REPVLPPQKM GPMEKFWNKF LENKSPWRKM
VHGVYQKSIF VFTHVLVPVW IIHYYMKYHV SEKPYGIVEK KSRIFPGDTI LETGEVIPPM
KEFPDQHH
