NDUB7_BOVIN
ID NDUB7_BOVIN Reviewed; 137 AA.
AC Q02368; Q3T0A1;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7;
DE AltName: Full=Complex I-B18;
DE Short=CI-B18;
DE AltName: Full=NADH-ubiquinone oxidoreductase B18 subunit;
GN Name=NDUFB7;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], MYRISTOYLATION AT GLY-2, AND PARTIAL PROTEIN
RP SEQUENCE.
RC TISSUE=Heart;
RX PubMed=1518044; DOI=10.1016/0022-2836(92)91052-q;
RA Walker J.E., Arizmendi J.M., Dupuis A., Fearnley I.M., Finel M., Medd S.M.,
RA Pilkington S.J., Runswick M.J., Skehel J.M.;
RT "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine
RT heart mitochondria. Application of a novel strategy for sequencing proteins
RT using the polymerase chain reaction.";
RL J. Mol. Biol. 226:1051-1072(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PARTIAL PROTEIN SEQUENCE, SUBUNIT, IDENTIFICATION IN COMPLEX I, AND
RP SUBCELLULAR LOCATION.
RX PubMed=10852722; DOI=10.1021/bi000335t;
RA Sazanov L.A., Peak-Chew S.Y., Fearnley I.M., Walker J.E.;
RT "Resolution of the membrane domain of bovine complex I into subcomplexes:
RT implications for the structural organization of the enzyme.";
RL Biochemistry 39:7229-7235(2000).
RN [4]
RP SUBUNIT, IDENTIFICATION IN COMPLEX I, AND SUBCELLULAR LOCATION.
RX PubMed=18721790; DOI=10.1016/j.ab.2008.07.029;
RA Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A.,
RA Robinson N.C.;
RT "Subunit analysis of bovine heart complex I by reversed-phase high-
RT performance liquid chromatography, electrospray ionization-tandem mass
RT spectrometry, and matrix-assisted laser desorption/ionization-time-of-
RT flight mass spectrometry.";
RL Anal. Biochem. 382:116-121(2008).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:P17568}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000269|PubMed:10852722, ECO:0000269|PubMed:1518044,
CC ECO:0000269|PubMed:18721790}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000305|PubMed:10852722, ECO:0000305|PubMed:18721790}; Peripheral
CC membrane protein {ECO:0000305}. Mitochondrion intermembrane space
CC {ECO:0000305}.
CC -!- DOMAIN: Contains two C-X9-C motifs that are predicted to form a helix-
CC coil-helix structure, permitting the formation of intramolecular
CC disulfide bonds. {ECO:0000250|UniProtKB:P17568}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB7 subunit family.
CC {ECO:0000305}.
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DR EMBL; X63210; CAA44895.1; -; mRNA.
DR EMBL; BC102482; AAI02483.1; -; mRNA.
DR PIR; S28247; S28247.
DR RefSeq; NP_788833.1; NM_176660.2.
DR PDB; 5LC5; EM; 4.35 A; o=58-115.
DR PDB; 5LDW; EM; 4.27 A; o=2-137.
DR PDB; 5LDX; EM; 5.60 A; o=58-115.
DR PDB; 5O31; EM; 4.13 A; o=2-137.
DR PDB; 7QSD; EM; 3.10 A; o=1-137.
DR PDBsum; 5LC5; -.
DR PDBsum; 5LDW; -.
DR PDBsum; 5LDX; -.
DR PDBsum; 5O31; -.
DR PDBsum; 7QSD; -.
DR AlphaFoldDB; Q02368; -.
DR SMR; Q02368; -.
DR CORUM; Q02368; -.
DR DIP; DIP-38797N; -.
DR IntAct; Q02368; 1.
DR STRING; 9913.ENSBTAP00000016768; -.
DR TCDB; 3.D.1.6.1; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR iPTMnet; Q02368; -.
DR PaxDb; Q02368; -.
DR PRIDE; Q02368; -.
DR Ensembl; ENSBTAT00000016768; ENSBTAP00000016768; ENSBTAG00000012634.
DR GeneID; 338065; -.
DR KEGG; bta:338065; -.
DR CTD; 4713; -.
DR VEuPathDB; HostDB:ENSBTAG00000012634; -.
DR VGNC; VGNC:31966; NDUFB7.
DR eggNOG; KOG3468; Eukaryota.
DR GeneTree; ENSGT00390000018759; -.
DR HOGENOM; CLU_154847_1_0_1; -.
DR InParanoid; Q02368; -.
DR OMA; FVYQCAH; -.
DR OrthoDB; 1570033at2759; -.
DR TreeFam; TF315152; -.
DR Reactome; R-BTA-611105; Respiratory electron transport.
DR Reactome; R-BTA-6799198; Complex I biogenesis.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000012634; Expressed in laryngeal cartilage and 105 other tissues.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR008698; NDUB7.
DR PANTHER; PTHR20900; PTHR20900; 1.
DR Pfam; PF05676; NDUF_B7; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Disulfide bond;
KW Electron transport; Lipoprotein; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Myristate; Phosphoprotein;
KW Reference proteome; Respiratory chain; Transport.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..137
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 7"
FT /id="PRO_0000118810"
FT DOMAIN 56..98
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT REGION 110..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 59..69
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 80..90
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CR61"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000269|PubMed:1518044"
FT DISULFID 59..90
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 69..80
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 137 AA; 16398 MW; F75B1365E32DC573 CRC64;
MGAHLARRYL GDASVEPDPL RMPTFPPDYG FPERKEREMV ATQQEMNDAQ LVLQQRDYCA
HYLIRFLKCK RDSFPNFLAC KHERHDWDYC EHLDYVKRMK EFERERRLLQ RKKRREQREA
DMAKGLGPGE VAPEVAL
