ID   NDUB8_PANTR             Reviewed;         186 AA.
AC   Q0MQE7;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial;
DE   AltName: Full=Complex I-ASHI;
DE            Short=CI-ASHI;
DE   AltName: Full=NADH-ubiquinone oxidoreductase ASHI subunit;
DE   Flags: Precursor;
GN   Name=NDUFB8;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA   Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA   Wallace D.C.;
RT   "Adaptive selection of mitochondrial complex I subunits during primate
RT   radiation.";
RL   Gene 378:11-18(2006).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O95169}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:O95169}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O95169}; Single-pass membrane protein
CC       {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O95169}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFB8 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; DQ885687; ABH12196.1; -; mRNA.
DR   RefSeq; NP_001138336.1; NM_001144864.1.
DR   AlphaFoldDB; Q0MQE7; -.
DR   SMR; Q0MQE7; -.
DR   STRING; 9598.ENSPTRP00000005010; -.
DR   PaxDb; Q0MQE7; -.
DR   GeneID; 744716; -.
DR   KEGG; ptr:744716; -.
DR   CTD; 4714; -.
DR   eggNOG; KOG4040; Eukaryota.
DR   HOGENOM; CLU_108654_1_0_1; -.
DR   InParanoid; Q0MQE7; -.
DR   OrthoDB; 1427659at2759; -.
DR   TreeFam; TF317319; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR008699; NDUFB8.
DR   InterPro; IPR016551; Ndufb8_metazoa.
DR   PANTHER; PTHR12840; PTHR12840; 1.
DR   Pfam; PF05821; NDUF_B8; 1.
DR   PIRSF; PIRSF009288; NDUB8; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Respiratory chain; Transit peptide; Transmembrane;
KW   Transmembrane helix; Transport.
FT   TRANSIT         1..28
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..186
FT                   /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT                   subunit 8, mitochondrial"
FT                   /id="PRO_0000251842"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   186 AA;  21780 MW;  5191AC344965C818 CRC64;
     MAVARAGVLG VQWLQRASRN VMPLGARTAS HMTKDMFPGP YPRTPEERAA AAKKYNMRVE
     DYEPYPDDGM GYGDYPKLPD RSQHERDPWY SWDQPGLRLN WGEPMHWHLD MYNRNRVDTS
     PTPLSWHVMC MQLFGFLAFM IFMCWVGDVY PVYQPVGPKQ YPYNNLYLER GGDPSKEPER
     VVHYEI