ID   NDUB8_PONAB             Reviewed;         186 AA.
AC   P0CB85; Q0MQE5; Q5NVJ1; Q5R4A8;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial;
DE   AltName: Full=Complex I-ASHI;
DE            Short=CI-ASHI;
DE   AltName: Full=NADH-ubiquinone oxidoreductase ASHI subunit;
DE   Flags: Precursor;
GN   Name=NDUFB8;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O95169}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:O95169}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O95169}; Single-pass membrane protein
CC       {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O95169}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFB8 subunit family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR861347; CAH93408.1; -; mRNA.
DR   EMBL; CR926037; CAI29672.1; -; mRNA.
DR   RefSeq; NP_001127101.1; NM_001133629.1.
DR   AlphaFoldDB; P0CB85; -.
DR   SMR; P0CB85; -.
DR   STRING; 9601.ENSPPYP00000002983; -.
DR   GeneID; 100174138; -.
DR   KEGG; pon:100174138; -.
DR   CTD; 4714; -.
DR   eggNOG; KOG4040; Eukaryota.
DR   InParanoid; P0CB85; -.
DR   OrthoDB; 1427659at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR008699; NDUFB8.
DR   InterPro; IPR016551; Ndufb8_metazoa.
DR   PANTHER; PTHR12840; PTHR12840; 1.
DR   Pfam; PF05821; NDUF_B8; 1.
DR   PIRSF; PIRSF009288; NDUB8; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Respiratory chain; Transit peptide; Transmembrane;
KW   Transmembrane helix; Transport.
FT   TRANSIT         1..28
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..186
FT                   /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT                   subunit 8, mitochondrial"
FT                   /id="PRO_0000233982"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        183
FT                   /note="H -> R (in Ref. 1; CAI29672)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   186 AA;  21857 MW;  1EB32AFA0FB94941 CRC64;
     MAVARAGVLG VQWLQRASWN VMPLGARTAS HMTKDMFPGP YPRTPEERAA AAKKYNMRVE
     DYEPYPDDGM GYGDYPKLPD RSQHERDPWY SWDQPDLRLN WGEPMHWHLD MFNRNRVDTS
     PILVSWNVMC MQLFGFLAFM IFMCWVGEVY PVYQPVGPKQ YPYNNLYLER GGDPSKEPER
     VVHYEI