ID   NDUB8_PONPY             Reviewed;         186 AA.
AC   P0CB86; Q0MQE5; Q5NVJ1; Q5R4A8;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial;
DE   AltName: Full=Complex I-ASHI;
DE            Short=CI-ASHI;
DE   AltName: Full=NADH-ubiquinone oxidoreductase ASHI subunit;
DE   Flags: Precursor;
GN   Name=NDUFB8;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA   Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA   Wallace D.C.;
RT   "Adaptive selection of mitochondrial complex I subunits during primate
RT   radiation.";
RL   Gene 378:11-18(2006).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000250|UniProtKB:O95169}.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:O95169}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:O95169}; Single-pass membrane protein
CC       {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O95169}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFB8 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; DQ885689; ABH12198.1; -; mRNA.
DR   AlphaFoldDB; P0CB86; -.
DR   SMR; P0CB86; -.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR008699; NDUFB8.
DR   InterPro; IPR016551; Ndufb8_metazoa.
DR   PANTHER; PTHR12840; PTHR12840; 1.
DR   Pfam; PF05821; NDUF_B8; 1.
DR   PIRSF; PIRSF009288; NDUB8; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Respiratory chain; Transit peptide; Transmembrane; Transmembrane helix;
KW   Transport.
FT   TRANSIT         1..28
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..186
FT                   /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT                   subunit 8, mitochondrial"
FT                   /id="PRO_0000389249"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   186 AA;  21903 MW;  3D30FDA32DB6F810 CRC64;
     MAVARTGVLG VQWLQRASWN MMPLGARTAS HMTKDMFPGP YPRTPEERAA AAKKYNMRVE
     DYEPYPDDGM GYGDYPKLPD RSQHERDPWY SWDQPDLRLN WGEPMHWHLD MFNRNRVDTS
     PIPVSWNVMC MQLFGFLAFM IFMCWVGEVY PVYQPVGPKQ YPYNNLYLER GGDPSKEPER
     VVHYEI