NDUBA_BOVIN
ID NDUBA_BOVIN Reviewed; 176 AA.
AC Q02373; Q3ZC99;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10;
DE AltName: Full=Complex I-PDSW;
DE Short=CI-PDSW;
DE AltName: Full=NADH-ubiquinone oxidoreductase PDSW subunit;
GN Name=NDUFB10;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Heart;
RX PubMed=1518044; DOI=10.1016/0022-2836(92)91052-q;
RA Walker J.E., Arizmendi J.M., Dupuis A., Fearnley I.M., Finel M., Medd S.M.,
RA Pilkington S.J., Runswick M.J., Skehel J.M.;
RT "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine
RT heart mitochondria. Application of a novel strategy for sequencing proteins
RT using the polymerase chain reaction.";
RL J. Mol. Biol. 226:1051-1072(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PARTIAL PROTEIN SEQUENCE, SUBUNIT, IDENTIFICATION IN COMPLEX I, AND
RP SUBCELLULAR LOCATION.
RX PubMed=10852722; DOI=10.1021/bi000335t;
RA Sazanov L.A., Peak-Chew S.Y., Fearnley I.M., Walker J.E.;
RT "Resolution of the membrane domain of bovine complex I into subcomplexes:
RT implications for the structural organization of the enzyme.";
RL Biochemistry 39:7229-7235(2000).
RN [4]
RP SUBUNIT, IDENTIFICATION IN COMPLEX I, AND SUBCELLULAR LOCATION.
RX PubMed=18721790; DOI=10.1016/j.ab.2008.07.029;
RA Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A.,
RA Robinson N.C.;
RT "Subunit analysis of bovine heart complex I by reversed-phase high-
RT performance liquid chromatography, electrospray ionization-tandem mass
RT spectrometry, and matrix-assisted laser desorption/ionization-time-of-
RT flight mass spectrometry.";
RL Anal. Biochem. 382:116-121(2008).
CC -!- FUNCTION: Accessory subunit that is involved in the functional assembly
CC of the mitochondrial respiratory chain complex I. Complex I has an NADH
CC dehydrogenase activity with ubiquinone as an immediate electron
CC acceptor and mediates the transfer of electrons from NADH to the
CC respiratory chain. {ECO:0000250|UniProtKB:O96000}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits
CC (PubMed:10852722, PubMed:1518044, PubMed:18721790). Interacts with
CC CHCHD4. {ECO:0000250|UniProtKB:O96000, ECO:0000269|PubMed:10852722,
CC ECO:0000269|PubMed:1518044, ECO:0000269|PubMed:18721790}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000305|PubMed:10852722, ECO:0000305|PubMed:18721790}; Peripheral
CC membrane protein; Matrix side.
CC -!- SIMILARITY: Belongs to the complex I NDUFB10 subunit family.
CC {ECO:0000305}.
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DR EMBL; X63224; CAA44909.1; -; mRNA.
DR EMBL; BC102700; AAI02701.1; -; mRNA.
DR PIR; S28253; S28253.
DR RefSeq; NP_787012.1; NM_175818.4.
DR PDB; 5LC5; EM; 4.35 A; p=77-143.
DR PDB; 5LDW; EM; 4.27 A; p=77-143.
DR PDB; 5LDX; EM; 5.60 A; p=77-143.
DR PDB; 5O31; EM; 4.13 A; p=77-143.
DR PDB; 7QSD; EM; 3.10 A; p=1-176.
DR PDBsum; 5LC5; -.
DR PDBsum; 5LDW; -.
DR PDBsum; 5LDX; -.
DR PDBsum; 5O31; -.
DR PDBsum; 7QSD; -.
DR AlphaFoldDB; Q02373; -.
DR SMR; Q02373; -.
DR CORUM; Q02373; -.
DR DIP; DIP-38806N; -.
DR IntAct; Q02373; 2.
DR STRING; 9913.ENSBTAP00000012542; -.
DR PaxDb; Q02373; -.
DR PRIDE; Q02373; -.
DR Ensembl; ENSBTAT00000012542; ENSBTAP00000012542; ENSBTAG00000009534.
DR GeneID; 327701; -.
DR KEGG; bta:327701; -.
DR CTD; 4716; -.
DR VEuPathDB; HostDB:ENSBTAG00000009534; -.
DR VGNC; VGNC:31960; NDUFB10.
DR eggNOG; KOG4009; Eukaryota.
DR GeneTree; ENSGT00390000006348; -.
DR HOGENOM; CLU_112615_1_0_1; -.
DR InParanoid; Q02373; -.
DR OMA; ERMKACQ; -.
DR OrthoDB; 1364322at2759; -.
DR TreeFam; TF105792; -.
DR Reactome; R-BTA-611105; Respiratory electron transport.
DR Reactome; R-BTA-6799198; Complex I biogenesis.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000009534; Expressed in laryngeal cartilage and 106 other tissues.
DR ExpressionAtlas; Q02373; baseline and differential.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR019377; NADH_UbQ_OxRdtase_su10.
DR InterPro; IPR039993; NDUFB10.
DR PANTHER; PTHR13094; PTHR13094; 1.
DR Pfam; PF10249; NDUFB10; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Electron transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Phosphoprotein;
KW Reference proteome; Respiratory chain; Transport.
FT CHAIN 1..176
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 10"
FT /id="PRO_0000118829"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 151
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O96000"
SQ SEQUENCE 176 AA; 20965 MW; F4409C8D49AE0AB4 CRC64;
MPDSWDKDVY PEPPRRTPAP SPQTSLPNPI TYLTKAFDLL VDRPVTLVRE FIERQHAKNK
YYYYHREFRR VPDITECQEK DVLCMFEAEM QWRRDYKVDQ EIVNIIQERL KACQQREGES
HRQNCAKELE QFTQVVKAYQ DRYHDLGAHY SARKCLAKQK QRMLAERKAA KEAAAA
