NDUBB_BOVIN
ID NDUBB_BOVIN Reviewed; 154 AA.
AC Q8HXG5; Q3T137;
DT 27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial;
DE AltName: Full=Complex I-ESSS;
DE Short=CI-ESSS;
DE AltName: Full=NADH-ubiquinone oxidoreductase ESSS subunit;
DE Flags: Precursor;
GN Name=NDUFB11;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 22-154, AND PROTEIN SEQUENCE OF 30-47.
RC TISSUE=Heart;
RX PubMed=12381726; DOI=10.1074/jbc.m209166200;
RA Carroll J., Shannon R.J., Fearnley I.M., Walker J.E., Hirst J.;
RT "Definition of the nuclear encoded protein composition of bovine heart
RT mitochondrial complex I. Identification two new subunits.";
RL J. Biol. Chem. 277:50311-50317(2002).
RN [3]
RP SUBUNIT, IDENTIFICATION IN COMPLEX I, AND SUBCELLULAR LOCATION.
RX PubMed=18721790; DOI=10.1016/j.ab.2008.07.029;
RA Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A.,
RA Robinson N.C.;
RT "Subunit analysis of bovine heart complex I by reversed-phase high-
RT performance liquid chromatography, electrospray ionization-tandem mass
RT spectrometry, and matrix-assisted laser desorption/ionization-time-of-
RT flight mass spectrometry.";
RL Anal. Biochem. 382:116-121(2008).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:Q9NX14}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits. Interacts with
CC BCAP31. {ECO:0000250|UniProtKB:Q9NX14}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9NX14}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9NX14}. Note=The interaction with BCAP31
CC mediates mitochondria localization. {ECO:0000250|UniProtKB:Q9NX14}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB11 subunit family.
CC {ECO:0000305}.
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DR EMBL; BC102141; AAI02142.1; -; mRNA.
DR EMBL; AJ510149; CAD52868.1; -; mRNA.
DR RefSeq; NP_001028792.1; NM_001033620.2.
DR PDB; 5LC5; EM; 4.35 A; g=1-154.
DR PDB; 5LDW; EM; 4.27 A; g=30-154.
DR PDB; 5LDX; EM; 5.60 A; g=30-154.
DR PDB; 5O31; EM; 4.13 A; g=30-154.
DR PDB; 7QSD; EM; 3.10 A; g=1-154.
DR PDBsum; 5LC5; -.
DR PDBsum; 5LDW; -.
DR PDBsum; 5LDX; -.
DR PDBsum; 5O31; -.
DR PDBsum; 7QSD; -.
DR AlphaFoldDB; Q8HXG5; -.
DR SMR; Q8HXG5; -.
DR CORUM; Q8HXG5; -.
DR DIP; DIP-38813N; -.
DR IntAct; Q8HXG5; 2.
DR STRING; 9913.ENSBTAP00000055738; -.
DR TCDB; 3.D.1.6.1; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR PaxDb; Q8HXG5; -.
DR PRIDE; Q8HXG5; -.
DR Ensembl; ENSBTAT00000070642; ENSBTAP00000067442; ENSBTAG00000051287.
DR GeneID; 404161; -.
DR KEGG; bta:404161; -.
DR CTD; 54539; -.
DR VEuPathDB; HostDB:ENSBTAG00000051287; -.
DR VGNC; VGNC:31961; NDUFB11.
DR eggNOG; KOG4808; Eukaryota.
DR GeneTree; ENSGT00390000003022; -.
DR HOGENOM; CLU_109862_0_0_1; -.
DR InParanoid; Q8HXG5; -.
DR OMA; CAQSHFR; -.
DR OrthoDB; 1609364at2759; -.
DR TreeFam; TF314671; -.
DR Reactome; R-BTA-611105; Respiratory electron transport.
DR Reactome; R-BTA-6799198; Complex I biogenesis.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000051287; Expressed in tongue muscle and 103 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR019329; NADH_UbQ_OxRdtase_ESSS_su.
DR PANTHER; PTHR13327; PTHR13327; 1.
DR Pfam; PF10183; ESSS; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Electron transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Respiratory chain; Transit peptide; Transmembrane; Transmembrane helix;
KW Transport.
FT TRANSIT 1..29
FT /note="Mitochondrion"
FT /evidence="ECO:0000269|PubMed:12381726"
FT CHAIN 30..154
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 11, mitochondrial"
FT /id="PRO_0000020056"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 40..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 154 AA; 17573 MW; 5D0B30342901D748 CRC64;
MAARMLGLCG RRLLAVAATR GLPAARVRWE SSSSRAVIAP STLAGKRPSE PTLRWQEDPE
PEDENLYEKN PDSHGYDKDP AVDIWNMRVV FFFGFSIVLV LGSTFVAYLP DYRMQEWARR
EAERLVKYRE AHGLPIMESN CFDPSKIQLP EDED
