NDUBB_CRIGR
ID NDUBB_CRIGR Reviewed; 151 AA.
AC Q6DQX6;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial;
DE AltName: Full=Complex I-ESSS;
DE Short=CI-ESSS;
DE AltName: Full=NADH-ubiquinone oxidoreductase ESSS subunit;
DE Flags: Precursor;
GN Name=NDUFB11;
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15265046; DOI=10.1111/j.1432-1033.2004.04260.x;
RA Potluri P., Yadava N., Scheffler I.E.;
RT "The role of the ESSS protein in the assembly of a functional and stable
RT mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase).";
RL Eur. J. Biochem. 271:3265-3273(2004).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:Q9NX14}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits. Interacts with
CC BCAP31. {ECO:0000250|UniProtKB:Q9NX14}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9NX14}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9NX14}. Note=The interaction with BCAP31
CC mediates mitochondria localization. {ECO:0000250|UniProtKB:Q9NX14}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB11 subunit family.
CC {ECO:0000305}.
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DR EMBL; AY649405; AAT69237.1; -; mRNA.
DR RefSeq; NP_001233718.1; NM_001246789.1.
DR AlphaFoldDB; Q6DQX6; -.
DR SMR; Q6DQX6; -.
DR STRING; 10029.NP_001233718.1; -.
DR Ensembl; ENSCGRT00001009851; ENSCGRP00001006288; ENSCGRG00001008464.
DR GeneID; 100689361; -.
DR KEGG; cge:100689361; -.
DR CTD; 54539; -.
DR eggNOG; KOG4808; Eukaryota.
DR GeneTree; ENSGT00390000003022; -.
DR OMA; CAQSHFR; -.
DR OrthoDB; 1609364at2759; -.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR019329; NADH_UbQ_OxRdtase_ESSS_su.
DR PANTHER; PTHR13327; PTHR13327; 1.
DR Pfam; PF10183; ESSS; 1.
PE 2: Evidence at transcript level;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Respiratory chain; Transit peptide; Transmembrane; Transmembrane helix;
KW Transport.
FT TRANSIT 1..29
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 30..151
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 11, mitochondrial"
FT /id="PRO_0000234303"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 39..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 151 AA; 17485 MW; 63781C815551BB1E CRC64;
MAARLLSLCA RRLSVTAAVR GLPAAGVRWE SSRAVISPST VERKRQRQPT MHWQEDPESE
DENVYAKNPD FHGYDQDPVV DVWNMRVVFF FGFSIVLVLG TTFMAYLPDY RMQEWARREA
ERLVKYREAN GLPIMESNCF DPSKIQLPED E