NDUC1_BOVIN
ID NDUC1_BOVIN Reviewed; 76 AA.
AC Q02376; Q3T0H7;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial;
DE AltName: Full=Complex I-KFYI;
DE Short=CI-KFYI;
DE AltName: Full=NADH-ubiquinone oxidoreductase KFYI subunit;
DE Flags: Precursor;
GN Name=NDUFC1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Heart;
RX PubMed=1518044; DOI=10.1016/0022-2836(92)91052-q;
RA Walker J.E., Arizmendi J.M., Dupuis A., Fearnley I.M., Finel M., Medd S.M.,
RA Pilkington S.J., Runswick M.J., Skehel J.M.;
RT "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine
RT heart mitochondria. Application of a novel strategy for sequencing proteins
RT using the polymerase chain reaction.";
RL J. Mol. Biol. 226:1051-1072(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PARTIAL PROTEIN SEQUENCE, SUBUNIT, IDENTIFICATION IN COMPLEX I, AND
RP SUBCELLULAR LOCATION.
RX PubMed=10852722; DOI=10.1021/bi000335t;
RA Sazanov L.A., Peak-Chew S.Y., Fearnley I.M., Walker J.E.;
RT "Resolution of the membrane domain of bovine complex I into subcomplexes:
RT implications for the structural organization of the enzyme.";
RL Biochemistry 39:7229-7235(2000).
RN [4]
RP SUBUNIT, IDENTIFICATION IN COMPLEX I, AND SUBCELLULAR LOCATION.
RX PubMed=18721790; DOI=10.1016/j.ab.2008.07.029;
RA Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A.,
RA Robinson N.C.;
RT "Subunit analysis of bovine heart complex I by reversed-phase high-
RT performance liquid chromatography, electrospray ionization-tandem mass
RT spectrometry, and matrix-assisted laser desorption/ionization-time-of-
RT flight mass spectrometry.";
RL Anal. Biochem. 382:116-121(2008).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O43677}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000269|PubMed:10852722, ECO:0000269|PubMed:1518044,
CC ECO:0000269|PubMed:18721790}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000305|PubMed:10852722, ECO:0000305|PubMed:18721790}; Single-pass
CC membrane protein; Matrix side.
CC -!- SIMILARITY: Belongs to the complex I NDUFC1 subunit family.
CC {ECO:0000305}.
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DR EMBL; X63214; CAA44899.1; -; mRNA.
DR EMBL; BC102392; AAI02393.1; -; mRNA.
DR PIR; S28250; S28250.
DR RefSeq; NP_776989.1; NM_174564.2.
DR RefSeq; XP_005217593.1; XM_005217536.2.
DR PDB; 5LC5; EM; 4.35 A; c=1-76.
DR PDB; 5LDW; EM; 4.27 A; c=28-76.
DR PDB; 5LDX; EM; 5.60 A; c=28-76.
DR PDB; 5LNK; EM; 3.90 A; x=28-76.
DR PDB; 5O31; EM; 4.13 A; c=28-76.
DR PDB; 7QSD; EM; 3.10 A; c=1-76.
DR PDBsum; 5LC5; -.
DR PDBsum; 5LDW; -.
DR PDBsum; 5LDX; -.
DR PDBsum; 5LNK; -.
DR PDBsum; 5O31; -.
DR PDBsum; 7QSD; -.
DR AlphaFoldDB; Q02376; -.
DR SMR; Q02376; -.
DR CORUM; Q02376; -.
DR DIP; DIP-38817N; -.
DR IntAct; Q02376; 1.
DR STRING; 9913.ENSBTAP00000051891; -.
DR TCDB; 3.D.1.6.1; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR PaxDb; Q02376; -.
DR PRIDE; Q02376; -.
DR Ensembl; ENSBTAT00000055713; ENSBTAP00000051891; ENSBTAG00000039582.
DR GeneID; 282289; -.
DR KEGG; bta:282289; -.
DR CTD; 4717; -.
DR VEuPathDB; HostDB:ENSBTAG00000039582; -.
DR VGNC; VGNC:31968; NDUFC1.
DR eggNOG; ENOG502SFTF; Eukaryota.
DR GeneTree; ENSGT00390000002565; -.
DR HOGENOM; CLU_199185_0_0_1; -.
DR InParanoid; Q02376; -.
DR OMA; SAFIWGL; -.
DR OrthoDB; 1622769at2759; -.
DR TreeFam; TF338333; -.
DR Proteomes; UP000009136; Chromosome 17.
DR Bgee; ENSBTAG00000039582; Expressed in oocyte and 105 other tissues.
DR ExpressionAtlas; Q02376; baseline.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR026192; NDUFC1.
DR PANTHER; PTHR17097; PTHR17097; 1.
DR Pfam; PF15088; NADH_dh_m_C1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Electron transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Respiratory chain; Transit peptide; Transmembrane; Transmembrane helix;
KW Transport.
FT TRANSIT 1..27
FT /note="Mitochondrion"
FT CHAIN 28..76
FT /note="NADH dehydrogenase [ubiquinone] 1 subunit C1,
FT mitochondrial"
FT /id="PRO_0000020048"
FT TRANSMEM 41..59
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 76 AA; 8784 MW; 326286716C4394F9 CRC64;
MAPSALLRPF WKLLAPARFP SVSSSRSKFY IQEPPHGSPN WLKVGLTLGT SVFLWIYLIK
QHNEDVLEYK RRNGLE
