NDUC1_GORGO
ID NDUC1_GORGO Reviewed; 76 AA.
AC Q0MQF5;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial;
DE AltName: Full=Complex I-KFYI;
DE Short=CI-KFYI;
DE AltName: Full=NADH-ubiquinone oxidoreductase KFYI subunit;
DE Flags: Precursor;
GN Name=NDUFC1;
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA Wallace D.C.;
RT "Adaptive selection of mitochondrial complex I subunits during primate
RT radiation.";
RL Gene 378:11-18(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O43677}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O43677}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q02376}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q02376}; Matrix side
CC {ECO:0000250|UniProtKB:Q02376}.
CC -!- SIMILARITY: Belongs to the complex I NDUFC1 subunit family.
CC {ECO:0000305}.
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DR EMBL; DQ885679; ABH12188.1; -; mRNA.
DR RefSeq; XP_004040447.1; XM_004040399.2.
DR RefSeq; XP_004040450.1; XM_004040402.2.
DR RefSeq; XP_004040451.1; XM_004040403.2.
DR AlphaFoldDB; Q0MQF5; -.
DR SMR; Q0MQF5; -.
DR STRING; 9593.ENSGGOP00000004732; -.
DR Ensembl; ENSGGOT00000004854; ENSGGOP00000004732; ENSGGOG00000004832.
DR Ensembl; ENSGGOT00000063777; ENSGGOP00000047456; ENSGGOG00000004832.
DR GeneID; 101134553; -.
DR KEGG; ggo:101134553; -.
DR CTD; 4717; -.
DR eggNOG; ENOG502SFTF; Eukaryota.
DR GeneTree; ENSGT00390000002565; -.
DR HOGENOM; CLU_199185_0_0_1; -.
DR InParanoid; Q0MQF5; -.
DR OMA; SAFIWGL; -.
DR OrthoDB; 1622769at2759; -.
DR Proteomes; UP000001519; Chromosome 4.
DR Bgee; ENSGGOG00000004832; Expressed in heart and 6 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR026192; NDUFC1.
DR PANTHER; PTHR17097; PTHR17097; 1.
DR Pfam; PF15088; NADH_dh_m_C1; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Respiratory chain; Transit peptide; Transmembrane;
KW Transmembrane helix; Transport.
FT TRANSIT 1..27
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 28..76
FT /note="NADH dehydrogenase [ubiquinone] 1 subunit C1,
FT mitochondrial"
FT /id="PRO_0000251848"
FT TRANSMEM 41..59
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 76 AA; 8720 MW; 7EEDEDE4618DFB5E CRC64;
MAPSALLRPL SRLLAPARLP SGPSVRSKFY VREPPNAKPD WLKVGFTLGT TVFLWVYLIK
QHNEDILEYK RRNGLE
