NDUC1_MOUSE
ID NDUC1_MOUSE Reviewed; 76 AA.
AC Q9CQY9; Q58DY9;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial;
DE AltName: Full=Complex I-KFYI;
DE Short=CI-KFYI;
DE AltName: Full=NADH-ubiquinone oxidoreductase KFYI subunit;
DE Flags: Precursor;
GN Name=Ndufc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Kidney, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O43677}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O43677}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q02376}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q02376}; Matrix side
CC {ECO:0000250|UniProtKB:Q02376}.
CC -!- SIMILARITY: Belongs to the complex I NDUFC1 subunit family.
CC {ECO:0000305}.
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DR EMBL; AK003365; BAB22739.1; -; mRNA.
DR EMBL; AK009393; BAB26262.1; -; mRNA.
DR EMBL; AK018705; BAB31356.1; -; mRNA.
DR EMBL; AK028011; BAC25698.1; -; mRNA.
DR EMBL; BC092141; AAH92141.1; -; mRNA.
DR CCDS; CCDS38426.1; -.
DR RefSeq; NP_079799.1; NM_025523.1.
DR PDB; 6G2J; EM; 3.30 A; c=1-76.
DR PDB; 6G72; EM; 3.90 A; c=1-76.
DR PDB; 6ZR2; EM; 3.10 A; c=1-76.
DR PDB; 6ZTQ; EM; 3.00 A; c=1-76.
DR PDB; 7AK5; EM; 3.17 A; c=1-76.
DR PDB; 7AK6; EM; 3.82 A; c=1-76.
DR PDB; 7B93; EM; 3.04 A; c=1-76.
DR PDB; 7PSA; EM; 3.40 A; c=1-76.
DR PDBsum; 6G2J; -.
DR PDBsum; 6G72; -.
DR PDBsum; 6ZR2; -.
DR PDBsum; 6ZTQ; -.
DR PDBsum; 7AK5; -.
DR PDBsum; 7AK6; -.
DR PDBsum; 7B93; -.
DR PDBsum; 7PSA; -.
DR AlphaFoldDB; Q9CQY9; -.
DR SMR; Q9CQY9; -.
DR ComplexPortal; CPX-266; Mitochondrial respiratory chain complex I.
DR IntAct; Q9CQY9; 1.
DR STRING; 10090.ENSMUSP00000038463; -.
DR PhosphoSitePlus; Q9CQY9; -.
DR MaxQB; Q9CQY9; -.
DR PaxDb; Q9CQY9; -.
DR PRIDE; Q9CQY9; -.
DR ProteomicsDB; 287468; -.
DR TopDownProteomics; Q9CQY9; -.
DR Antibodypedia; 49615; 55 antibodies from 21 providers.
DR DNASU; 66377; -.
DR Ensembl; ENSMUST00000038108; ENSMUSP00000038463; ENSMUSG00000037152.
DR Ensembl; ENSMUST00000193279; ENSMUSP00000141933; ENSMUSG00000037152.
DR GeneID; 66377; -.
DR KEGG; mmu:66377; -.
DR UCSC; uc008pdy.1; mouse.
DR CTD; 4717; -.
DR MGI; MGI:1913627; Ndufc1.
DR VEuPathDB; HostDB:ENSMUSG00000037152; -.
DR eggNOG; ENOG502SFTF; Eukaryota.
DR GeneTree; ENSGT00390000002565; -.
DR HOGENOM; CLU_199185_0_0_1; -.
DR InParanoid; Q9CQY9; -.
DR OMA; SAFIWGL; -.
DR OrthoDB; 1622769at2759; -.
DR PhylomeDB; Q9CQY9; -.
DR TreeFam; TF338333; -.
DR Reactome; R-MMU-611105; Respiratory electron transport.
DR Reactome; R-MMU-6799198; Complex I biogenesis.
DR BioGRID-ORCS; 66377; 7 hits in 72 CRISPR screens.
DR ChiTaRS; Ndufc1; mouse.
DR PRO; PR:Q9CQY9; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9CQY9; protein.
DR Bgee; ENSMUSG00000037152; Expressed in hindlimb stylopod muscle and 247 other tissues.
DR Genevisible; Q9CQY9; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:MGI.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0009060; P:aerobic respiration; IC:ComplexPortal.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR GO; GO:0042776; P:proton motive force-driven mitochondrial ATP synthesis; IC:ComplexPortal.
DR InterPro; IPR026192; NDUFC1.
DR PANTHER; PTHR17097; PTHR17097; 1.
DR Pfam; PF15088; NADH_dh_m_C1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transit peptide; Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..27
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 28..76
FT /note="NADH dehydrogenase [ubiquinone] 1 subunit C1,
FT mitochondrial"
FT /id="PRO_0000020050"
FT TRANSMEM 40..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT STRAND 35..38
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 41..72
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT TURN 73..75
FT /evidence="ECO:0007829|PDB:7B93"
SQ SEQUENCE 76 AA; 8625 MW; 3EF9EE9B8D2367F8 CRC64;
MAPSVVLRSF SRLLAPARLP SCSSTRSKFY VREPVNAKPN WLAVGLSVGA SVFMWIYLIQ
THNEDVLEYK RRNGLE
