NDUC1_PANTR
ID NDUC1_PANTR Reviewed; 76 AA.
AC Q0MQF6;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial;
DE AltName: Full=Complex I-KFYI;
DE Short=CI-KFYI;
DE AltName: Full=NADH-ubiquinone oxidoreductase KFYI subunit;
DE Flags: Precursor;
GN Name=NDUFC1;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA Wallace D.C.;
RT "Adaptive selection of mitochondrial complex I subunits during primate
RT radiation.";
RL Gene 378:11-18(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O43677}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O43677}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q02376}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q02376}; Matrix side
CC {ECO:0000250|UniProtKB:Q02376}.
CC -!- SIMILARITY: Belongs to the complex I NDUFC1 subunit family.
CC {ECO:0000305}.
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DR EMBL; DQ885678; ABH12187.1; -; mRNA.
DR RefSeq; XP_016807722.1; XM_016952233.1.
DR RefSeq; XP_016807723.1; XM_016952234.1.
DR RefSeq; XP_016807724.1; XM_016952235.1.
DR RefSeq; XP_016807725.1; XM_016952236.1.
DR RefSeq; XP_016807727.1; XM_016952238.1.
DR RefSeq; XP_016807728.1; XM_016952239.1.
DR RefSeq; XP_016807729.1; XM_016952240.1.
DR AlphaFoldDB; Q0MQF6; -.
DR SMR; Q0MQF6; -.
DR Ensembl; ENSPTRT00000076892; ENSPTRP00000079068; ENSPTRG00000046657.
DR GeneID; 461494; -.
DR KEGG; ptr:461494; -.
DR CTD; 4717; -.
DR GeneTree; ENSGT01020000234452; -.
DR InParanoid; Q0MQF6; -.
DR OMA; SAFIWGL; -.
DR OrthoDB; 1622769at2759; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000046657; Expressed in heart and 20 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR026192; NDUFC1.
DR PANTHER; PTHR17097; PTHR17097; 1.
DR Pfam; PF15088; NADH_dh_m_C1; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Respiratory chain; Transit peptide; Transmembrane;
KW Transmembrane helix; Transport.
FT TRANSIT 1..27
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 28..76
FT /note="NADH dehydrogenase [ubiquinone] 1 subunit C1,
FT mitochondrial"
FT /id="PRO_0000251849"
FT TRANSMEM 41..59
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 76 AA; 8734 MW; 7EEDEDE477E12B5E CRC64;
MAPSALLRPL SRLLAPARLP SGPSVRSKFY VREPPNAKPD WLKVGFTLGT TVFLWIYLIK
QHNEDILEYK RRNGLE
