NDUC2_MACFA
ID NDUC2_MACFA Reviewed; 119 AA.
AC Q8SPI4;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 subunit C2 {ECO:0000250|UniProtKB:O95298};
DE AltName: Full=Complex I-B14.5b;
DE Short=CI-B14.5b;
DE AltName: Full=NADH-ubiquinone oxidoreductase subunit B14.5b;
GN Name=NDUFC2 {ECO:0000250|UniProtKB:O95298}; ORFNames=QccE-12975;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RX PubMed=11991714; DOI=10.1006/geno.2002.6753;
RA Osada N., Kusuda J., Hirata M., Tanuma R., Hida M., Sugano S., Hirai M.,
RA Hashimoto K.;
RT "Search for genes positively selected during primate evolution by 5'-end-
RT sequence screening of cynomolgus monkey cDNAs.";
RL Genomics 79:657-662(2002).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis but required for the complex assembly. Complex I
CC functions in the transfer of electrons from NADH to the respiratory
CC chain. The immediate electron acceptor for the enzyme is believed to be
CC ubiquinone. {ECO:0000250|UniProtKB:O95298}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits. Interacts with
CC TMEM242 (By similarity). {ECO:0000250|UniProtKB:O95298}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O95298}; Single-pass membrane protein
CC {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O95298}.
CC -!- SIMILARITY: Belongs to the complex I NDUFC2 subunit family.
CC {ECO:0000305}.
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DR EMBL; AB072016; BAB86805.1; -; mRNA.
DR RefSeq; NP_001274114.1; NM_001287185.1.
DR AlphaFoldDB; Q8SPI4; -.
DR SMR; Q8SPI4; -.
DR STRING; 9541.XP_005579237.1; -.
DR PRIDE; Q8SPI4; -.
DR Ensembl; ENSMFAT00000087666; ENSMFAP00000053235; ENSMFAG00000030802.
DR GeneID; 102116918; -.
DR CTD; 4718; -.
DR VEuPathDB; HostDB:ENSMFAG00000030802; -.
DR eggNOG; KOG4516; Eukaryota.
DR GeneTree; ENSGT00390000010352; -.
DR OMA; WFIGYHL; -.
DR OrthoDB; 1606491at2759; -.
DR Proteomes; UP000233100; Chromosome 14.
DR Bgee; ENSMFAG00000030802; Expressed in skeletal muscle tissue and 13 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR009423; NDUC2.
DR PANTHER; PTHR13099; PTHR13099; 1.
DR Pfam; PF06374; NDUF_C2; 1.
DR PIRSF; PIRSF017834; NADH-UbQ_OxRdtase_b14.5b; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Respiratory chain; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..119
FT /note="NADH dehydrogenase [ubiquinone] 1 subunit C2"
FT /id="PRO_0000118838"
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 119 AA; 14244 MW; 2A3054C4C2CC869E CRC64;
MVPRRNPEPL RFLPDESRSL PPPKLTDPRL LYVGFLGYCA GLVDNFIHRR PIRSAGLHRH
LLYITAFYFV GYYLVKRGDY TYAVRDREMF GYMKLHPEDF SEKEKKTYAE IFEKFHPIR
