NDUC2_PONPY
ID NDUC2_PONPY Reviewed; 119 AA.
AC Q0MQF7;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 subunit C2 {ECO:0000250|UniProtKB:O95298};
DE AltName: Full=Complex I-B14.5b;
DE Short=CI-B14.5b;
DE AltName: Full=NADH-ubiquinone oxidoreductase subunit B14.5b;
GN Name=NDUFC2 {ECO:0000250|UniProtKB:O95298};
OS Pongo pygmaeus (Bornean orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA Wallace D.C.;
RT "Adaptive selection of mitochondrial complex I subunits during primate
RT radiation.";
RL Gene 378:11-18(2006).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis but required for the complex assembly. Complex I
CC functions in the transfer of electrons from NADH to the respiratory
CC chain. The immediate electron acceptor for the enzyme is believed to be
CC ubiquinone. {ECO:0000250|UniProtKB:O95298}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits. Interacts with
CC TMEM242 (By similarity). {ECO:0000250|UniProtKB:O95298}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O95298}; Single-pass membrane protein
CC {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O95298}.
CC -!- SIMILARITY: Belongs to the complex I NDUFC2 subunit family.
CC {ECO:0000305}.
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DR EMBL; DQ885677; ABH12186.1; -; mRNA.
DR AlphaFoldDB; Q0MQF7; -.
DR SMR; Q0MQF7; -.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR009423; NDUC2.
DR PANTHER; PTHR13099; PTHR13099; 1.
DR Pfam; PF06374; NDUF_C2; 1.
DR PIRSF; PIRSF017834; NADH-UbQ_OxRdtase_b14.5b; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..119
FT /note="NADH dehydrogenase [ubiquinone] 1 subunit C2"
FT /id="PRO_0000251852"
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 119 AA; 14182 MW; E9BDB964691252FC CRC64;
MIARRNPEPL RFLPDEARSL PPPKLTDPRL LYLGFLGYCS GLIDNLIRRR PIATAGLHRQ
LLYITAFFFA GYYLVKRENY LYAVRDREMF GYMKLHPEEF PEEEKKTYGE IFEKFHPVH