NDUF2_MOUSE
ID NDUF2_MOUSE Reviewed; 168 AA.
AC Q59J78; Q14A56; Q80VX9;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2;
DE AltName: Full=Mimitin {ECO:0000250|UniProtKB:Q8N183};
DE AltName: Full=Myc-induced mitochondrial protein {ECO:0000250|UniProtKB:Q8N183};
DE Short=MMTN {ECO:0000250|UniProtKB:Q8N183};
DE AltName: Full=NDUFA12-like protein;
DE Flags: Precursor;
GN Name=Ndufaf2; Synonyms=Ndufa12l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15774466; DOI=10.1074/jbc.m501231200;
RA Tsuneoka M., Teye K., Arima N., Soejima M., Otera H., Ohashi K., Koga Y.,
RA Fujita H., Shirouzu K., Kimura H., Koda Y.;
RT "A novel Myc-target gene, mimitin, that is involved in cell proliferation
RT of esophageal squamous cell carcinoma.";
RL J. Biol. Chem. 280:19977-19985(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Li X., Jin Y., Yue W., Yan W., Liu Y.;
RT "A candidate gene related to development of cleft palate.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Acts as a molecular chaperone for mitochondrial complex I
CC assembly. Complex I functions in the transfer of electrons from NADH to
CC the respiratory chain. The immediate electron acceptor for the enzyme
CC is believed to be ubiquinone. {ECO:0000250|UniProtKB:Q8N183}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8N183}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA12 subunit family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP33449.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB183434; BAD91206.1; -; mRNA.
DR EMBL; AY262012; AAP33449.1; ALT_FRAME; mRNA.
DR EMBL; BC116975; AAI16976.1; -; mRNA.
DR EMBL; BC116977; AAI16978.1; -; mRNA.
DR CCDS; CCDS49357.1; -.
DR RefSeq; NP_001120818.1; NM_001127346.1.
DR AlphaFoldDB; Q59J78; -.
DR SMR; Q59J78; -.
DR STRING; 10090.ENSMUSP00000130532; -.
DR iPTMnet; Q59J78; -.
DR PhosphoSitePlus; Q59J78; -.
DR EPD; Q59J78; -.
DR MaxQB; Q59J78; -.
DR PaxDb; Q59J78; -.
DR PeptideAtlas; Q59J78; -.
DR PRIDE; Q59J78; -.
DR ProteomicsDB; 293644; -.
DR Ensembl; ENSMUST00000163558; ENSMUSP00000130532; ENSMUSG00000068184.
DR GeneID; 75597; -.
DR KEGG; mmu:75597; -.
DR UCSC; uc007ruu.2; mouse.
DR CTD; 91942; -.
DR MGI; MGI:1922847; Ndufaf2.
DR VEuPathDB; HostDB:ENSMUSG00000068184; -.
DR eggNOG; ENOG502S21I; Eukaryota.
DR GeneTree; ENSGT00390000002743; -.
DR HOGENOM; CLU_138027_0_0_1; -.
DR InParanoid; Q59J78; -.
DR OMA; VPEYKNW; -.
DR OrthoDB; 1394421at2759; -.
DR PhylomeDB; Q59J78; -.
DR TreeFam; TF314761; -.
DR Reactome; R-MMU-6799198; Complex I biogenesis.
DR BioGRID-ORCS; 75597; 6 hits in 72 CRISPR screens.
DR ChiTaRS; Ndufaf2; mouse.
DR PRO; PR:Q59J78; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q59J78; protein.
DR Bgee; ENSMUSG00000068184; Expressed in manus and 221 other tissues.
DR ExpressionAtlas; Q59J78; baseline and differential.
DR Genevisible; Q59J78; MM.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:MGI.
DR GO; GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:MGI.
DR InterPro; IPR007763; NDUFA12.
DR Pfam; PF05071; NDUFA12; 1.
PE 1: Evidence at protein level;
KW Chaperone; Mitochondrion; Phosphoprotein; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..168
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT assembly factor 2"
FT /id="PRO_0000020055"
FT REGION 112..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 133
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N183"
SQ SEQUENCE 168 AA; 19628 MW; DB45BAF7DF4D7AD7 CRC64;
MSWWSGVWRS VWSALSREVR EHVGTDHLGN KYYYVAEYKN WRGQTIREKR IVEAANRKEV
DYEAGDIPTE WEAWIRRTRK TPPTMEEILK NEKYREEIKI KSQDFYEKDK LGKETSEELL
PSPTATQVKG HASAPYFGRE EPSVAPTSTG KTFQPGSWTP EDGKRQSQ
