NDUF3_MOUSE
ID NDUF3_MOUSE Reviewed; 185 AA.
AC Q9JKL4; Q8K1A3;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3;
DE AltName: Full=Protein 2P1;
GN Name=Ndufaf3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=12653254;
RA Hammami-Hamza S., Doussau M., Allemand I., Segretain D., Gasc J.-M.,
RA Finaz C.;
RT "2P1, a novel male mouse cDNA specifically expressed during meiosis.";
RL Int. J. Dev. Biol. 47:71-76(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Essential factor for the assembly of mitochondrial
CC NADH:ubiquinone oxidoreductase complex (complex I). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with NDUFAF4, NDUFS2 and NDUFS3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Mitochondrion inner
CC membrane {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in testis and weakly expressed
CC in the epididymis. Expressed in spermatocytes.
CC {ECO:0000269|PubMed:12653254}.
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DR EMBL; AF235017; AAF61723.1; -; mRNA.
DR EMBL; AK005252; BAB23907.1; -; mRNA.
DR EMBL; AK014634; BAB29477.1; -; mRNA.
DR EMBL; BC027513; AAH27513.1; -; mRNA.
DR CCDS; CCDS23531.1; -.
DR RefSeq; NP_075736.1; NM_023247.1.
DR AlphaFoldDB; Q9JKL4; -.
DR SMR; Q9JKL4; -.
DR BioGRID; 211659; 5.
DR IntAct; Q9JKL4; 1.
DR MINT; Q9JKL4; -.
DR STRING; 10090.ENSMUSP00000073832; -.
DR PhosphoSitePlus; Q9JKL4; -.
DR SwissPalm; Q9JKL4; -.
DR EPD; Q9JKL4; -.
DR jPOST; Q9JKL4; -.
DR MaxQB; Q9JKL4; -.
DR PaxDb; Q9JKL4; -.
DR PeptideAtlas; Q9JKL4; -.
DR PRIDE; Q9JKL4; -.
DR ProteomicsDB; 252869; -.
DR Antibodypedia; 48697; 80 antibodies from 16 providers.
DR Ensembl; ENSMUST00000074208; ENSMUSP00000073832; ENSMUSG00000070283.
DR GeneID; 66706; -.
DR KEGG; mmu:66706; -.
DR UCSC; uc009rqh.1; mouse.
DR CTD; 25915; -.
DR MGI; MGI:1913956; Ndufaf3.
DR VEuPathDB; HostDB:ENSMUSG00000070283; -.
DR eggNOG; KOG3363; Eukaryota.
DR GeneTree; ENSGT00390000018312; -.
DR HOGENOM; CLU_074390_3_1_1; -.
DR InParanoid; Q9JKL4; -.
DR OMA; FSKAYDH; -.
DR OrthoDB; 1569969at2759; -.
DR PhylomeDB; Q9JKL4; -.
DR TreeFam; TF321072; -.
DR Reactome; R-MMU-6799198; Complex I biogenesis.
DR BioGRID-ORCS; 66706; 19 hits in 58 CRISPR screens.
DR ChiTaRS; Ndufaf3; mouse.
DR PRO; PR:Q9JKL4; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9JKL4; protein.
DR Bgee; ENSMUSG00000070283; Expressed in heart left ventricle and 74 other tissues.
DR ExpressionAtlas; Q9JKL4; baseline and differential.
DR Genevisible; Q9JKL4; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISO:MGI.
DR CDD; cd05125; Mth938_2P1-like; 1.
DR Gene3D; 3.40.1230.10; -; 1.
DR InterPro; IPR036748; MTH938-like_sf.
DR InterPro; IPR034095; NDUF3.
DR InterPro; IPR007523; NDUFAF3/AAMDC.
DR PANTHER; PTHR21192; PTHR21192; 1.
DR Pfam; PF04430; DUF498; 1.
DR SUPFAM; SSF64076; SSF64076; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleus;
KW Reference proteome.
FT CHAIN 1..185
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT assembly factor 3"
FT /id="PRO_0000281155"
FT CONFLICT 89
FT /note="Q -> H (in Ref. 3; AAH27513)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 185 AA; 20734 MW; EB2095864254B757 CRC64;
MATALGFRCL FRTRPAPLCR HVDRLWRNPR RGHRLSPADD ELYQRTRISL LQSEFPQAVY
IDSYSSRGFT ICGNRVFGPC VLLPQTVVQW NVGSHQDITE ESFSLFWMLE PRIEIVVVGT
GNKTERLHPQ VLQAMRQRGI AVEVQDTPNA CATFNFLCHE GRVTGAALIP PPGETALASL
GQASE
