ID   NDUF4_BOVIN             Reviewed;         175 AA.
AC   A4FUH5;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4;
DE   AltName: Full=Hormone-regulated proliferation-associated protein of 20 kDa;
GN   Name=NDUFAF4; Synonyms=HRPAP20;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the assembly of mitochondrial NADH:ubiquinone
CC       oxidoreductase complex (complex I) (By similarity). May be involved in
CC       cell proliferation and survival of hormone-dependent tumor cells. May
CC       be a regulator of breast tumor cell invasion (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds calmodulin. Interacts with NDUFAF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Membrane
CC       {ECO:0000250|UniProtKB:Q9P032}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q9P032}.
CC   -!- PTM: Phosphorylated on serine. Prolactin stimulate serine
CC       phosphorylation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDUFAF4 family. {ECO:0000305}.
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DR   EMBL; BC114895; AAI14896.1; -; mRNA.
DR   RefSeq; NP_001076985.1; NM_001083516.1.
DR   AlphaFoldDB; A4FUH5; -.
DR   SMR; A4FUH5; -.
DR   STRING; 9913.ENSBTAP00000004122; -.
DR   PaxDb; A4FUH5; -.
DR   PRIDE; A4FUH5; -.
DR   Ensembl; ENSBTAT00000004122; ENSBTAP00000004122; ENSBTAG00000003174.
DR   GeneID; 615440; -.
DR   KEGG; bta:615440; -.
DR   CTD; 29078; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003174; -.
DR   VGNC; VGNC:31956; NDUFAF4.
DR   eggNOG; KOG4481; Eukaryota.
DR   GeneTree; ENSGT00390000001627; -.
DR   HOGENOM; CLU_054693_2_0_1; -.
DR   InParanoid; A4FUH5; -.
DR   OMA; IPDQKYK; -.
DR   OrthoDB; 1395543at2759; -.
DR   TreeFam; TF323532; -.
DR   Reactome; R-BTA-6799198; Complex I biogenesis.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000003174; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IBA:GO_Central.
DR   InterPro; IPR009622; NDUFAF4.
DR   PANTHER; PTHR13338; PTHR13338; 1.
DR   Pfam; PF06784; UPF0240; 1.
PE   2: Evidence at transcript level;
KW   Calmodulin-binding; Lipoprotein; Membrane; Mitochondrion; Myristate;
KW   Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P032"
FT   CHAIN           2..175
FT                   /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT                   assembly factor 4"
FT                   /id="PRO_0000342667"
FT   REGION          16..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         35
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P032"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P032"
SQ   SEQUENCE   175 AA;  20108 MW;  1421A22152BEBB58 CRC64;
     MGAAVARAVR NFNLENRAER EISRMKPSPA PRHPSTKNLL LEQMSSHPEI KGEIDRKDDK
     LLSLLKDVYV DSQDPVSSLQ VKDATARQKP KEFRLPKDHQ FDMMDVKNIP KGKISIVEAL
     TLLNNHKLYP DTWTAKKIAE EYHLEQQDVN SLLKYFVTFE VKIFPPEGKK AIESK